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Sensitivity of Immediate and Delayed Gadolinium-Enhanced MRI After Injection of 0.5 M and 1.0 M Gadolinium Chelates for Detecting Multiple Sclerosis Lesions

Ender Uysal1, Sukru Mehmet Erturk1, Hakan Yildirim1, Feray Seleker2 and Muzaffer Basak1

1 Department of Radiology, Sisli Etfal Hospital, Etfal Sok, Istanbul 80220, Turkey.
2 Department of Neurology, Sisli Etfal Hospital, Istanbul 80220, Turkey.


Figure 1
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  		Fig. 1A —35-year-old man with multiple sclerosis. Axial fast spin-echo T2-weighted image (TR/TE, 4,800/102; inversion time, 2 milliseconds) shows plaque lesion at left side of pons near tectum.

 

Figure 2
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  		Fig. 1B —35-year-old man with multiple sclerosis. Ten minutes after IV administration of 0.5-mol/L contrast medium (0.1 mmol/kg), no contrast enhancement attributable to this lesion is detectable on magnetization transfer contrast-enhanced T1-weighted image (560/15; inversion time, 1 millisecond).

 

Figure 3
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  		Fig. 1C —35-year-old man with multiple sclerosis. Immediately after administration of 1.0-mol/L contrast medium (0.2 mmol/kg), focal contrast enhancement (arrowhead) is barely detectable.

 

Figure 4
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  		Fig. 1D —35-year-old man with multiple sclerosis. However, 5 (D) and 10 (E) minutes after administration of 1.0-mol/L contrast medium (0.2 mmol/kg), enhancement is clearly visible in this lesion.

 

Figure 5
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  		Fig. 1E —35-year-old man with multiple sclerosis. However, 5 (D) and 10 (E) minutes after administration of 1.0-mol/L contrast medium (0.2 mmol/kg), enhancement is clearly visible in this lesion.

 

Figure 6
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  		Fig. 2A —27-year-old woman with multiple sclerosis (MS). Millimetric MS plaque lesions are seen in subcortical white matter and at periventricular region on axial fast spin-echo T2-weighted image.

 

Figure 7
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  		Fig. 2B —27-year-old woman with multiple sclerosis (MS). Ten minutes after IV administration of 0.5-mol/L contrast medium (0.1 mmol/kg), no contrast enhancement attributable to a white matter lesion is detectable on magnetization transfer contrast-enhanced T1-weighted image.

 

Figure 8
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  		Fig. 2C —27-year-old woman with multiple sclerosis (MS). Immediately after administration of 1.0-mol/L contrast medium (0.2 mmol/kg), there is also no contrast enhancement.

 

Figure 9
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  		Fig. 2D —27-year-old woman with multiple sclerosis (MS). However, 5 (D) and 10 (E) minutes after administration of 1.0-mol/L contrast medium (0.2 mmol/kg), one enhancing lesion (arrowhead) is detectable in frontal left lobe. Note that enhancement is more prominent on latest image.

 

Figure 10
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  		Fig. 2E —27-year-old woman with multiple sclerosis (MS). However, 5 (D) and 10 (E) minutes after administration of 1.0-mol/L contrast medium (0.2 mmol/kg), one enhancing lesion (arrowhead) is detectable in frontal left lobe. Note that enhancement is more prominent on latest image.

 

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