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Subtraction Imaging: Applications for Nonvascular Abdominal MRI

Amit Newatia1, Gaurav Khatri, Barak Friedman and John Hines

1 All authors: Department of Radiology, Long Island Jewish Medical Center, 270-05 76th Ave., New Hyde Park, NY 11040.


Figure 1
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Fig. 1A —49-year-old woman with acute flank pain. Unenhanced axial CT scan at level of kidneys shows large acute subcapsular hematoma (arrows) in midpole of left kidney.

 

Figure 2
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Fig. 1B —49-year-old woman with acute flank pain. Contrast-enhanced axial CT scan shows peripheral areas of high attenuation (arrows); however, differentiation of enhancement versus high-density blood is difficult.

 

Figure 3
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Fig. 1C —49-year-old woman with acute flank pain. Axial T1-weighted spoiled gradient-recalled echo (SPGR) fat-suppressed image shows heterogeneous signal intensity (arrowheads) within area of hemorrhage.

 

Figure 4
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Fig. 1D —49-year-old woman with acute flank pain. Axial T1-weighted SPGR contrast-enhanced image shows high signal intensity in periphery of hematoma (arrows) suggestive of enhancing tumor.

 

Figure 5
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Fig. 1E —49-year-old woman with acute flank pain. Axial subtraction image confirms presence of enhancing peripheral mass (black arrows) and signal void hematoma (white arrow). Large hemorrhagic renal cell carcinoma was found at nephrectomy.

 

Figure 6
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Fig. 2A —74-year-old man with known history of right adrenal mass who presented for MRI for further characterization. Axial T1-weighted fat-suppressed spoiled gradient-recalled echo (SPGR) image shows 7-cm right adrenal mass with areas of high signal intensity suggestive of hemorrhage (arrow). LK = left kidney.

 

Figure 7
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Fig. 2B —74-year-old man with known history of right adrenal mass who presented for MRI for further characterization. Axial T1-weighted fat-suppressed SPGR gadolinium-enhanced image again shows areas of high signal intensity (arrow). It is difficult to ascertain whether this is due to enhancement or hemorrhage. LK = left kidney.

 

Figure 8
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Fig. 2C —74-year-old man with known history of right adrenal mass who presented for MRI for further characterization. Axial subtraction image shows lack of enhancement within this mass (arrow) consistent with simple hemorrhage. Because of high clinical suspicion for malignancy, patient underwent adrenalectomy. Pathology showed presence of hemorrhage without evidence of neoplasm. Patient was later found to have myelofibrosis. LK = left kidney.

 

Figure 9
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Fig. 3A —72-year-old man with hemorrhagic splenic mass on CT (not shown) and questionable history of trauma. Axial T1-weighted fat-suppressed spoiled gradient-recalled echo (SPGR) unenhanced image through spleen shows large heterogeneous mass with areas of high signal intensity (arrowheads) and more central, focal hyperintense area (arrow). S = spleen.

 

Figure 10
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Fig. 3B —72-year-old man with hemorrhagic splenic mass on CT (not shown) and questionable history of trauma. Axial T1-weighted fat-suppressed SPGR contrast-enhanced image shows enhancement of normal splenic parenchyma (arrows). However, it is difficult to determine whether there is enhancement within mass. S = spleen.

 

Figure 11
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Fig. 3C —72-year-old man with hemorrhagic splenic mass on CT (not shown) and questionable history of trauma. Subtraction image shows definite areas of enhancement consistent with neoplasm (arrowheads). Areas of hematoma are signal void (arrow). Hemorrhagic lymphoma was found at splenectomy. S = spleen.

 

Figure 12
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Fig. 4A —25-year-old woman after attempted resection of pelvic sidewall mass. Initial pathology only showed hematoma. MRI was performed to determine presence of residual tumor. Axial T1-weighted fat-suppressed spoiled gradient-recalled echo (SPGR) unenhanced image shows hyperintense mass (black arrow) in left perivesical space, displacing urinary bladder to right. Second mass (white arrow) of mixed signal intensity is identified posterior and inferior in relation to this mass with displacement of rectum and lower uterine segment to right (asterisk).

 

Figure 13
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Fig. 4B —25-year-old woman after attempted resection of pelvic sidewall mass. Initial pathology only showed hematoma. MRI was performed to determine presence of residual tumor. T1-weighted fat-suppressed SPGR gadolinium-enhanced image shows similar areas of high signal intensity in both lesions (arrows).

 

Figure 14
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Fig. 4C —25-year-old woman after attempted resection of pelvic sidewall mass. Initial pathology only showed hematoma. MRI was performed to determine presence of residual tumor. Axial subtraction image shows marked enhancement of deep left pelvic mass (black arrows) confirming presence of residual neoplasm. Left perivesical mass (white arrow) is now signal void, consistent with postoperative hematoma. Pathologic reanalysis showed desmoid tumor.

 

Figure 15
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Fig. 5A —45-year-old man presenting with hematuria. Unenhanced CT scan shows indeterminate hyperdense, exophytic renal mass (arrow) in midpole of left kidney. MRI was performed to exclude underlying mass.

 

Figure 16
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Fig. 5B —45-year-old man presenting with hematuria. Axial T1-weighted spoiled gradient-recalled echo (SPGR) unenhanced MR image shows high signal intensity within renal mass (arrow).

 

Figure 17
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Fig. 5C —45-year-old man presenting with hematuria. It is difficult to visually determine whether high signal within mass (arrow) is due to enhancement or to intrinsic T1 brightness from hemorrhage or protein.

 

Figure 18
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Fig. 5D —45-year-old man presenting with hematuria. Axial subtraction image shows complete lack of enhancement within lesion (arrow), consistent with benign cyst.

 

Figure 19
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Fig. 6A —36-year-old man with metastatic disease to ribs and spine, without known primary tumor. Contrast-enhanced CT image shows indeterminate small left renal lesion (arrow).

 

Figure 20
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Fig. 6B —36-year-old man with metastatic disease to ribs and spine, without known primary tumor. Axial T1-weighted fat-suppressed spoiled gradient-recalled echo (SPGR) unenhanced image shows mildly hyperintense mass in upper pole of left kidney (arrow).

 

Figure 21
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Fig. 6C —36-year-old man with metastatic disease to ribs and spine, without known primary tumor. Axial T1-weighted fat-suppressed SPGR contrast-enhanced image. It is difficult to determine whether high signal intensity within mass (arrow) is due to enhancement or intrinsic high signal.

 

Figure 22
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Fig. 6D —36-year-old man with metastatic disease to ribs and spine, without known primary tumor. Axial subtraction image clearly shows nodular internal enhancement (arrow), consistent with small renal cell carcinoma. Biopsy of bone lesion showed carcinoma consistent with renal origin.

 

Figure 23
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Fig. 7A —65-year-old cirrhotic man after radiofrequency ablation for hepatocellular carcinoma. Axial T1-weighted fat-suppressed spoiled gradient-recalled echo (SPGR) unenhanced image shows heterogeneous but mostly hyperintense mass (arrowheads).

 

Figure 24
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Fig. 7B —65-year-old cirrhotic man after radiofrequency ablation for hepatocellular carcinoma. Axial T1-weighted fat-suppressed SPGR contrast-enhanced image shows areas of high signal intensity (arrows) that could be compatible with either hemorrhagic necrosis or tumor recurrence. Arrowheads indicate mass.

 

Figure 25
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Fig. 7C —65-year-old cirrhotic man after radiofrequency ablation for hepatocellular carcinoma. Axial T1 subtraction image shows conspicuous area of nodular enhancement, consistent with tumor recurrence (arrow). Arrowheads indicate mass.

 

Figure 26
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Fig. 8A —67-year-old man with fever secondary to Escherichia coli bacteremia. Contrast-enhanced axial CT image shows softtissue density along posterior wall of gallbladder (arrowheads). Differential diagnosis includes tumefactive sludge or gallbladder neoplasm.

 

Figure 27
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Fig. 8B —67-year-old man with fever secondary to Escherichia coli bacteremia. Axial T1-weighted fat-suppressed spoiled gradientrecalled echo (SPGR) unenhanced image shows isointense polypoid lesion (arrow) along posterior wall of gallbladder.

 

Figure 28
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Fig. 8C —67-year-old man with fever secondary to Escherichia coli bacteremia. Axial T1-weighted fat-suppressed SPGR contrastenhanced image shows probable enhancement within mass (arrow).

 

Figure 29
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Fig. 8D —67-year-old man with fever secondary to Escherichia coli bacteremia. Axial subtraction image shows avid enhancement of mass (arrow), highly suspicious for gallbladder neoplasm. Localized gallbladder cancer was found at cholecystectomy.

 

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