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Time-Resolved MR Angiography: A Primary Screening Examination of Patients with Suspected Pulmonary Embolism and Contraindications to Administration of Iodinated Contrast Material

Hale Ersoy1, Samuel Z. Goldhaber2, Tianxi Cai3, Tuan Luu1, Joshua Rosebrook1, Robert Mulkern4 and Frank Rybicki1

1 Cardiovascular Imaging Section, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis St., ASB I-L1-004, Boston, MA 02115.
2 Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
3 Department of Biostatistics, Harvard School of Public Health, Boston, MA.
4 Department of Radiology, Children's Hospital and Harvard Medical School, Boston, MA.


Figure 1
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Fig. 1 —46-year-old man with retrosternal chest pain and increasing shortness of breath for past 2 hours. Three-dimensional time-resolved pulmonary MR angiogram (TE/TR, 3.5/1.3; bandwidth, ± 62.5 kHz; flip angle, 35°, 30 partitions with effective thickness of 3 mm; matrix size, 256 x 192; scan time, 41 seconds) shows nine temporally resolved phases acquired with single breath-hold. Fourth phase has best image quality, as was true for most patients in this study.

 

Figure 2
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Fig. 2A —54-year-old man who underwent right antecubital vein injection and had unknown central venous thrombosis. Fifth phase of acquisition of coronal time-resolved 3D MR angiogram shows poor enhancement of pulmonary arteries (open arrows) due to slow venous flow from collateral veins.

 

Figure 3
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Fig. 2B —54-year-old man who underwent right antecubital vein injection and had unknown central venous thrombosis. Contrast-enhanced equilibrium phase 3D fast gradient-echo image shows thrombosis (arrows) of central veins.

 

Figure 4
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Fig. 3A —49-year-old woman with hypercoagulable state, shortness of breath, and bilateral leg swelling who underwent MR angiography followed by pulmonary embolism CT angiography within 24 hours. Coronal 3D MR angiogram (A) and source image from fourth phase of acquisition (B) show filling defect in left lower lobe artery (arrow).

 

Figure 5
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Fig. 3B —49-year-old woman with hypercoagulable state, shortness of breath, and bilateral leg swelling who underwent MR angiography followed by pulmonary embolism CT angiography within 24 hours. Coronal 3D MR angiogram (A) and source image from fourth phase of acquisition (B) show filling defect in left lower lobe artery (arrow).

 

Figure 6
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Fig. 3C —49-year-old woman with hypercoagulable state, shortness of breath, and bilateral leg swelling who underwent MR angiography followed by pulmonary embolism CT angiography within 24 hours. Coronal reformatted image from CT angiography confirms presence of pulmonary embolism (arrow) in anatomic area identical to A and B.

 

Figure 7
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Fig. 4A —56-year-old woman with chest pain, dyspnea, and lower extremity edema referred for pulmonary MR angiography. Intermediate-probability ventilation (A)-perfusion (B) lung scan obtained within 24 hours of MR angiography shows moderate ventilation-perfusion mismatch (curved arrow, B) in superior segment of right lower lobe.

 

Figure 8
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Fig. 4B —56-year-old woman with chest pain, dyspnea, and lower extremity edema referred for pulmonary MR angiography. Intermediate-probability ventilation (A)-perfusion (B) lung scan obtained within 24 hours of MR angiography shows moderate ventilation-perfusion mismatch (curved arrow, B) in superior segment of right lower lobe.

 

Figure 9
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Fig. 4C —56-year-old woman with chest pain, dyspnea, and lower extremity edema referred for pulmonary MR angiography. 3D MR angiographic image shows persistent partial filling defect (arrow) in right lower lobe pulmonary artery.

 

Figure 10
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Fig. 4D —56-year-old woman with chest pain, dyspnea, and lower extremity edema referred for pulmonary MR angiography. 3D MR angiographic source image shows abrupt cutoff of superior segmental branch of right lower lobe artery (open arrow).

 

Figure 11
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Fig. 5A —57-year-old man with chest pain, shortness of breath, and known renal cell carcinoma. 3D MR angiographic image shows no pulmonary embolism in pulmonary arterial system.

 

Figure 12
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Fig. 5B —57-year-old man with chest pain, shortness of breath, and known renal cell carcinoma. Contrast-enhanced equilibrium phase 3D fast gradient-echo image shows tumor plaque (arrow) in bronchus intermedius as result of direct invasion through subcarinal metastatic renal cell carcinoma. Atelectasis (open arrows) of right middle and right lower lobes also is evident.

 

Figure 13
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Fig. 6 —Drawing shows k-space segmentation for elliptic centric phase ordering for 3D time-resolved imaging of contrast kinetics MR angiographic acquisition. Segment A represents center of k-space (contrast enhancement). Segments B, C, and D represent periphery of k-space. kz = slice-encoding direction, ky = phase-encoding direction.

 

Figure 14
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Fig. 7 —Schematic shows temporal interpolation and view-sharing algorithm used for reconstruction of time-resolved MR angiographic images.

 

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