Time-Resolved MR Angiography: A Primary Screening Examination of Patients with Suspected Pulmonary Embolism and Contraindications to Administration of Iodinated Contrast Material
Hale Ersoy1,
Samuel Z. Goldhaber2,
Tianxi Cai3,
Tuan Luu1,
Joshua Rosebrook1,
Robert Mulkern4 and
Frank Rybicki1
1 Cardiovascular Imaging Section, Department of Radiology, Brigham and Women's
Hospital and Harvard Medical School, 75 Francis St., ASB I-L1-004, Boston, MA
02115.
2 Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard
Medical School, Boston, MA.
3 Department of Biostatistics, Harvard School of Public Health, Boston,
MA.
4 Department of Radiology, Children's Hospital and Harvard Medical School,
Boston, MA.

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Fig. 1 46-year-old man with retrosternal chest pain and increasing
shortness of breath for past 2 hours. Three-dimensional time-resolved
pulmonary MR angiogram (TE/TR, 3.5/1.3; bandwidth, ± 62.5 kHz; flip
angle, 35°, 30 partitions with effective thickness of 3 mm; matrix size,
256 x 192; scan time, 41 seconds) shows nine temporally resolved phases
acquired with single breath-hold. Fourth phase has best image quality, as was
true for most patients in this study.
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Fig. 2A 54-year-old man who underwent right antecubital vein injection and
had unknown central venous thrombosis. Fifth phase of acquisition of coronal
time-resolved 3D MR angiogram shows poor enhancement of pulmonary arteries
(open arrows) due to slow venous flow from collateral veins.
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Fig. 2B 54-year-old man who underwent right antecubital vein injection and
had unknown central venous thrombosis. Contrast-enhanced equilibrium phase 3D
fast gradient-echo image shows thrombosis (arrows) of central
veins.
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Fig. 3A 49-year-old woman with hypercoagulable state, shortness of breath,
and bilateral leg swelling who underwent MR angiography followed by pulmonary
embolism CT angiography within 24 hours. Coronal 3D MR angiogram (A)
and source image from fourth phase of acquisition (B) show filling
defect in left lower lobe artery (arrow).
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Fig. 3B 49-year-old woman with hypercoagulable state, shortness of breath,
and bilateral leg swelling who underwent MR angiography followed by pulmonary
embolism CT angiography within 24 hours. Coronal 3D MR angiogram (A)
and source image from fourth phase of acquisition (B) show filling
defect in left lower lobe artery (arrow).
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Fig. 3C 49-year-old woman with hypercoagulable state, shortness of breath,
and bilateral leg swelling who underwent MR angiography followed by pulmonary
embolism CT angiography within 24 hours. Coronal reformatted image from CT
angiography confirms presence of pulmonary embolism (arrow) in
anatomic area identical to A and B.
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Fig. 4A 56-year-old woman with chest pain, dyspnea, and lower extremity
edema referred for pulmonary MR angiography. Intermediate-probability
ventilation (A)-perfusion (B) lung scan obtained within 24 hours
of MR angiography shows moderate ventilation-perfusion mismatch (curved
arrow, B) in superior segment of right lower lobe.
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Fig. 4B 56-year-old woman with chest pain, dyspnea, and lower extremity
edema referred for pulmonary MR angiography. Intermediate-probability
ventilation (A)-perfusion (B) lung scan obtained within 24 hours
of MR angiography shows moderate ventilation-perfusion mismatch (curved
arrow, B) in superior segment of right lower lobe.
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Fig. 4C 56-year-old woman with chest pain, dyspnea, and lower extremity
edema referred for pulmonary MR angiography. 3D MR angiographic image shows
persistent partial filling defect (arrow) in right lower lobe
pulmonary artery.
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Fig. 4D 56-year-old woman with chest pain, dyspnea, and lower extremity
edema referred for pulmonary MR angiography. 3D MR angiographic source image
shows abrupt cutoff of superior segmental branch of right lower lobe artery
(open arrow).
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Fig. 5B 57-year-old man with chest pain, shortness of breath, and known
renal cell carcinoma. Contrast-enhanced equilibrium phase 3D fast
gradient-echo image shows tumor plaque (arrow) in bronchus
intermedius as result of direct invasion through subcarinal metastatic renal
cell carcinoma. Atelectasis (open arrows) of right middle and right
lower lobes also is evident.
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Fig. 6 Drawing shows k-space segmentation for elliptic centric phase
ordering for 3D time-resolved imaging of contrast kinetics MR angiographic
acquisition. Segment A represents center of k-space (contrast enhancement).
Segments B, C, and D represent periphery of k-space. kz = slice-encoding
direction, ky = phase-encoding direction.
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Copyright © 2007 by the American Roentgen Ray Society.