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Hippocampal Volume and the Mini-Mental State Examination in the Diagnosis of Amnestic Mild Cognitive Impairment

¹ School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
² School of Medicine, Duke University, Durham, NC.
³ Department of Radiology, Duke University Medical Center, 1527 Hospital Rd., Box 3808, Durham, NC, 27710.
⁴ Department of Psychiatry, Duke University Medical Center, Durham, NC.

View larger version (168K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1A —71-year-old man in normal health. Oblique coronal 1.5-mm MR images show bilateral hippocampal formations (crosshatching). For conciseness, only alternating slices are shown.

View larger version (167K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1B —71-year-old man in normal health. Oblique coronal 1.5-mm MR images show bilateral hippocampal formations (crosshatching). For conciseness, only alternating slices are shown.

View larger version (167K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1C —71-year-old man in normal health. Oblique coronal 1.5-mm MR images show bilateral hippocampal formations (crosshatching). For conciseness, only alternating slices are shown.

View larger version (167K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1D —71-year-old man in normal health. Oblique coronal 1.5-mm MR images show bilateral hippocampal formations (crosshatching). For conciseness, only alternating slices are shown.

View larger version (169K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1E —71-year-old man in normal health. Oblique coronal 1.5-mm MR images show bilateral hippocampal formations (crosshatching). For conciseness, only alternating slices are shown.

View larger version (168K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1F —71-year-old man in normal health. Oblique coronal 1.5-mm MR images show bilateral hippocampal formations (crosshatching). For conciseness, only alternating slices are shown.

View larger version (169K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1G —71-year-old man in normal health. Oblique coronal 1.5-mm MR images show bilateral hippocampal formations (crosshatching). For conciseness, only alternating slices are shown.

View larger version (169K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1H —71-year-old man in normal health. Oblique coronal 1.5-mm MR images show bilateral hippocampal formations (crosshatching). For conciseness, only alternating slices are shown.

View larger version (169K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1I —71-year-old man in normal health. Oblique coronal 1.5-mm MR images show bilateral hippocampal formations (crosshatching). For conciseness, only alternating slices are shown.

View larger version (168K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1J —71-year-old man in normal health. Oblique coronal 1.5-mm MR images show bilateral hippocampal formations (crosshatching). For conciseness, only alternating slices are shown.

View larger version (168K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1K —71-year-old man in normal health. Oblique coronal 1.5-mm MR images show bilateral hippocampal formations (crosshatching). For conciseness, only alternating slices are shown.

View larger version (164K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1L —71-year-old man in normal health. Oblique coronal 1.5-mm MR images show bilateral hippocampal formations (crosshatching). For conciseness, only alternating slices are shown.

View larger version (10K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2 —Graph shows receiver operating characteristic (ROC) curves of predicted probability of amnestic mild cognitive impairment based on hippocampal volumes compared with Mini-Mental State Examination (MMSE) score. Solid line indicates area under ROC curve (AUC) of 0.886 for left hippocampal volume; dashed line, AUC of 0.745 for MMSE; dotted line, AUC of 0.614 for right hippocampal volume.

View larger version (9K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 3 —Graph shows receiver operating characteristic (ROC) curve of predicted probability of amnestic mild cognitive impairment calculated from combined left hippocampal volume and Mini-Mental State Examination (MMSE) score compared with predicted probability based on MMSE score alone. Solid line indicates area under ROC curve (AUC) of 0.918 for combination of left hippocampal volume and MMSE; dotted line, AUC of 0.745 for MMSE.

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