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Monitoring Treatment Responses in Patients with Pulmonary TB Using Serial Lung Gallium-67 Scintigraphy

Shih-Feng Liu1, Jien-Wei Liu2, Meng-Chih Lin1, Chiang-Hsuan Lee3, Hsu-Hua Huang3 and Yung-Fa Lai1,4

1 Division of Pulmonary & Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Taiwan, ROC.
2 Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, 123, Ta Pei Rd., Niao Sung Hsiang, Kaohsiung Hsien 833, Taiwan, ROC.
3 Department of Nuclear Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Taiwan, ROC.
4 Present address: Chest Division, Department of Internal Medicine, E-Da Hospital, Taiwan, ROC.


Figure 1
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  		Fig. 1A —48-year-old man with pulmonary tuberculosis. Illustrations of changes in radionuclide uptake in serial 67Ga scintigraphy in one patient in this series.

 

Figure 2
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  		Fig. 1B —48-year-old man with pulmonary tuberculosis. Illustrations of changes in radionuclide uptake in serial 67Ga scintigraphy in one patient in this series.

 

Figure 3
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  		Fig. 1C —48-year-old man with pulmonary tuberculosis. Illustrations of changes in radionuclide uptake in serial 67Ga scintigraphy in one patient in this series.

 

Figure 4
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  		Fig. 2 —Semiquantitation of sputum acid-fast bacilli over time. Changes over time in pulmonary uptake of 67Ga citrate corresponding to varied burden of pulmonary Mycobacterium tuberculosis, indicated by semiquantitations of sputum acid-fast bacilli in enrolled patients receiving anti-TB treatment. Because plots from different patients in same chronologic assessment overlapped each other, Arabic numerals indicating numbers of overlapped plots were put in circles representing plots for specific intensity of pulmonary 67Ga uptake.

 

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