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Widespread Effects of Hyperintense Lesions on Cerebral White Matter Structure

Warren D. Taylor1,2, Jae Nam Bae1,2,3, James R. MacFall2,4, Martha E. Payne1,2, James M. Provenzale4, David C. Steffens1 and K. Ranga R. Krishnan1

1 Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, DUMC Box 3903, Durham, NC 27710.
2 Neuropsychiatric Imaging Research Laboratory, Duke University Medical Center, Durham, NC.
3 Present address: Department of Psychiatry, Inha University Hospital, Incheon, South Korea.
4 Department of Radiology, Duke University Medical Center, Durham, NC.


Figure 1
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  		Fig. 1 —Drawing shows brain parcellation for hyperintensity volume measurements. Axial plane was created along anterior commissure–posterior commissure (AC–PC) line. Next, coronal planes were created perpendicular to axial plane at anterior and posterior extents of corpus callosum. Finally, a third coronal plane was created at midpoint between first two coronal planes, dividing brain into anterior and posterior halves.

 

Figure 2
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  		Fig. 2A —Placement of regions of interest (ROIs). (Reprinted with permission from the Society of Biological Psychiatry: Bae JN, MacFall JR, Krishnan KR, Payne ME, Steffens DC, Taylor WD. Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression. Biol Psychiatry 2006; 60:1356–1363 [18]) ROIs in dorsolateral prefrontal cortex are shown for fractional anisotropy (FA) image (A), apparent diffusion coefficient (ADC) image (B), and T2-weighted image (C).

 

Figure 3
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  		Fig. 2B —Placement of regions of interest (ROIs). (Reprinted with permission from the Society of Biological Psychiatry: Bae JN, MacFall JR, Krishnan KR, Payne ME, Steffens DC, Taylor WD. Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression. Biol Psychiatry 2006; 60:1356–1363 [18]) ROIs in dorsolateral prefrontal cortex are shown for fractional anisotropy (FA) image (A), apparent diffusion coefficient (ADC) image (B), and T2-weighted image (C).

 

Figure 4
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  		Fig. 2C —Placement of regions of interest (ROIs). (Reprinted with permission from the Society of Biological Psychiatry: Bae JN, MacFall JR, Krishnan KR, Payne ME, Steffens DC, Taylor WD. Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression. Biol Psychiatry 2006; 60:1356–1363 [18]) ROIs in dorsolateral prefrontal cortex are shown for fractional anisotropy (FA) image (A), apparent diffusion coefficient (ADC) image (B), and T2-weighted image (C).

 

Figure 5
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  		Fig. 2D —Placement of regions of interest (ROIs). (Reprinted with permission from the Society of Biological Psychiatry: Bae JN, MacFall JR, Krishnan KR, Payne ME, Steffens DC, Taylor WD. Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression. Biol Psychiatry 2006; 60:1356–1363 [18]) ROIs in corpus callosum are shown for FA (D), ADC (E), and T2-weighted (F) images.

 

Figure 6
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  		Fig. 2E —Placement of regions of interest (ROIs). (Reprinted with permission from the Society of Biological Psychiatry: Bae JN, MacFall JR, Krishnan KR, Payne ME, Steffens DC, Taylor WD. Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression. Biol Psychiatry 2006; 60:1356–1363 [18]) ROIs in corpus callosum are shown for FA (D), ADC (E), and T2-weighted (F) images.

 

Figure 7
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  		Fig. 2F —Placement of regions of interest (ROIs). (Reprinted with permission from the Society of Biological Psychiatry: Bae JN, MacFall JR, Krishnan KR, Payne ME, Steffens DC, Taylor WD. Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression. Biol Psychiatry 2006; 60:1356–1363 [18]) ROIs in corpus callosum are shown for FA (D), ADC (E), and T2-weighted (F) images.

 

Figure 8
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  		Fig. 2G —Placement of regions of interest (ROIs). (Reprinted with permission from the Society of Biological Psychiatry: Bae JN, MacFall JR, Krishnan KR, Payne ME, Steffens DC, Taylor WD. Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression. Biol Psychiatry 2006; 60:1356–1363 [18]) ROIs in anterior cingulate cortex and internal capsule are shown for FA (G), ADC (H), and T2-weighted (I) images.

 

Figure 9
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  		Fig. 2H —Placement of regions of interest (ROIs). (Reprinted with permission from the Society of Biological Psychiatry: Bae JN, MacFall JR, Krishnan KR, Payne ME, Steffens DC, Taylor WD. Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression. Biol Psychiatry 2006; 60:1356–1363 [18]) ROIs in anterior cingulate cortex and internal capsule are shown for FA (G), ADC (H), and T2-weighted (I) images.

 

Figure 10
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  		Fig. 2I —Placement of regions of interest (ROIs). (Reprinted with permission from the Society of Biological Psychiatry: Bae JN, MacFall JR, Krishnan KR, Payne ME, Steffens DC, Taylor WD. Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression. Biol Psychiatry 2006; 60:1356–1363 [18]) ROIs in anterior cingulate cortex and internal capsule are shown for FA (G), ADC (H), and T2-weighted (I) images.

 

Figure 11
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  		Fig. 3A —Graphs show regional diffusion tensor imaging measures by anterior white matter (WM) lesion volume. ADC = apparent diffusion coefficient. Fractional anisotropy (FA) does not have units; because of space considerations, y-axis points are presented without decimal (e.g., 0.500 = 500 on graph).

 

Figure 12
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  		Fig. 3B —Graphs show regional diffusion tensor imaging measures by anterior white matter (WM) lesion volume. ADC = apparent diffusion coefficient. Fractional anisotropy (FA) does not have units; because of space considerations, y-axis points are presented without decimal (e.g., 0.500 = 500 on graph).

 

Figure 13
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  		Fig. 3C —Graphs show regional diffusion tensor imaging measures by anterior white matter (WM) lesion volume. ADC = apparent diffusion coefficient. Fractional anisotropy (FA) does not have units; because of space considerations, y-axis points are presented without decimal (e.g., 0.500 = 500 on graph).

 

Figure 14
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  		Fig. 3D —Graphs show regional diffusion tensor imaging measures by anterior white matter (WM) lesion volume. ADC = apparent diffusion coefficient. Fractional anisotropy (FA) does not have units; because of space considerations, y-axis points are presented without decimal (e.g., 0.500 = 500 on graph).

 

Figure 15
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  		Fig. 3E —Graphs show regional diffusion tensor imaging measures by anterior white matter (WM) lesion volume. ADC = apparent diffusion coefficient. Fractional anisotropy (FA) does not have units; because of space considerations, y-axis points are presented without decimal (e.g., 0.500 = 500 on graph).

 

Figure 16
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  		Fig. 3F —Graphs show regional diffusion tensor imaging measures by anterior white matter (WM) lesion volume. ADC = apparent diffusion coefficient. Fractional anisotropy (FA) does not have units; because of space considerations, y-axis points are presented without decimal (e.g., 0.500 = 500 on graph).

 

Figure 17
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  		Fig. 3G —Graphs show regional diffusion tensor imaging measures by anterior white matter (WM) lesion volume. ADC = apparent diffusion coefficient. Fractional anisotropy (FA) does not have units; because of space considerations, y-axis points are presented without decimal (e.g., 0.500 = 500 on graph).

 

Figure 18
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  		Fig. 3H —Graphs show regional diffusion tensor imaging measures by anterior white matter (WM) lesion volume. ADC = apparent diffusion coefficient. Fractional anisotropy (FA) does not have units; because of space considerations, y-axis points are presented without decimal (e.g., 0.500 = 500 on graph).

 

Figure 19
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  		Fig. 4A —Graphs show regional diffusion tensor imaging measures by anterior gray matter (GM) lesion volume. ADC = apparent diffusion coefficient. Fractional anisotropy (FA) does not have units; because of space considerations, y-axis points are presented without decimal (e.g., 0.500 = 500 on graph).

 

Figure 20
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  		Fig. 4B —Graphs show regional diffusion tensor imaging measures by anterior gray matter (GM) lesion volume. ADC = apparent diffusion coefficient. Fractional anisotropy (FA) does not have units; because of space considerations, y-axis points are presented without decimal (e.g., 0.500 = 500 on graph).

 

Figure 21
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  		Fig. 4C —Graphs show regional diffusion tensor imaging measures by anterior gray matter (GM) lesion volume. ADC = apparent diffusion coefficient. Fractional anisotropy (FA) does not have units; because of space considerations, y-axis points are presented without decimal (e.g., 0.500 = 500 on graph).

 

Figure 22
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  		Fig. 4D —Graphs show regional diffusion tensor imaging measures by anterior gray matter (GM) lesion volume. ADC = apparent diffusion coefficient. Fractional anisotropy (FA) does not have units; because of space considerations, y-axis points are presented without decimal (e.g., 0.500 = 500 on graph).

 

Figure 23
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  		Fig. 4E —Graphs show regional diffusion tensor imaging measures by anterior gray matter (GM) lesion volume. ADC = apparent diffusion coefficient. Fractional anisotropy (FA) does not have units; because of space considerations, y-axis points are presented without decimal (e.g., 0.500 = 500 on graph).

 

Figure 24
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  		Fig. 4F —Graphs show regional diffusion tensor imaging measures by anterior gray matter (GM) lesion volume. ADC = apparent diffusion coefficient. Fractional anisotropy (FA) does not have units; because of space considerations, y-axis points are presented without decimal (e.g., 0.500 = 500 on graph).

 

Figure 25
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  		Fig. 4G —Graphs show regional diffusion tensor imaging measures by anterior gray matter (GM) lesion volume. ADC = apparent diffusion coefficient. Fractional anisotropy (FA) does not have units; because of space considerations, y-axis points are presented without decimal (e.g., 0.500 = 500 on graph).

 

Figure 26
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  		Fig. 4H —Graphs show regional diffusion tensor imaging measures by anterior gray matter (GM) lesion volume. ADC = apparent diffusion coefficient. Fractional anisotropy (FA) does not have units; because of space considerations, y-axis points are presented without decimal (e.g., 0.500 = 500 on graph).

 

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