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Follicular Dendritic Cell Sarcoma of the Mediastinum

Jonathon A. Leipsic1, H. Page McAdams1 and Thomas A. Sporn2

1 Department of Radiology, Duke University Medical Center, PO Box 3808, Durham, NC 27710.
2 Department of Pathology, Duke University Medical Center, Durham, NC.


Figure 1
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  		Fig. 1A —Follicular dendritic cell sarcoma in 43-year-old man with chest pain. Posteroanterior (A) and lateral (B) chest radiographs show large, lobulated retrocardiac mass (arrows) on right. Note absence of calcification.

 

Figure 2
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  		Fig. 1B —Follicular dendritic cell sarcoma in 43-year-old man with chest pain. Posteroanterior (A) and lateral (B) chest radiographs show large, lobulated retrocardiac mass (arrows) on right. Note absence of calcification.

 

Figure 3
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  		Fig. 1C —Follicular dendritic cell sarcoma in 43-year-old man with chest pain. Sequential unenhanced CT images (mediastinal window settings) show that mass is lobulated in contour, is heterogeneous and of soft-tissue attenuation, and contains foci of rimlike and coarse calcification (arrowheads, D and F). Note also mass effect on left atrium (La, C), lateral displacement of esophagus (arrow, D), and small right pleural effusion (arrow, E).

 

Figure 4
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  		Fig. 1D —Follicular dendritic cell sarcoma in 43-year-old man with chest pain. Sequential unenhanced CT images (mediastinal window settings) show that mass is lobulated in contour, is heterogeneous and of soft-tissue attenuation, and contains foci of rimlike and coarse calcification (arrowheads, D and F). Note also mass effect on left atrium (La, C), lateral displacement of esophagus (arrow, D), and small right pleural effusion (arrow, E).

 

Figure 5
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  		Fig. 1E —Follicular dendritic cell sarcoma in 43-year-old man with chest pain. Sequential unenhanced CT images (mediastinal window settings) show that mass is lobulated in contour, is heterogeneous and of soft-tissue attenuation, and contains foci of rimlike and coarse calcification (arrowheads, D and F). Note also mass effect on left atrium (La, C), lateral displacement of esophagus (arrow, D), and small right pleural effusion (arrow, E).

 

Figure 6
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  		Fig. 1F —Follicular dendritic cell sarcoma in 43-year-old man with chest pain. Sequential unenhanced CT images (mediastinal window settings) show that mass is lobulated in contour, is heterogeneous and of soft-tissue attenuation, and contains foci of rimlike and coarse calcification (arrowheads, D and F). Note also mass effect on left atrium (La, C), lateral displacement of esophagus (arrow, D), and small right pleural effusion (arrow, E).

 

Figure 7
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  		Fig. 1G —Follicular dendritic cell sarcoma in 43-year-old man with chest pain. Photomicrograph shows cytologically bland spindle cells arranged in haphazard fashion, which is consistent with follicular dendritic cell sarcoma. Note absence of mitotic figures. (H and E stain, original magnification, x200)

 

Figure 8
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  		Fig. 1H —Follicular dendritic cell sarcoma in 43-year-old man with chest pain. Photomicrograph shows marked immunohistochemical staining for CD21 marker. (CD21 stain, original magnification, x200)

 

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