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Sonographic Diagnosis and Outcome of Hepatic Artery Thrombosis After Orthotopic Liver Transplantation in Adults

Mindy M. Horrow1, Beth M. Blumenthal1,2, David J. Reich3 and Cosme Manzarbeitia3

1 Department of Radiology, Albert Einstein Medical Center, 5501 Old York Rd., Philadelphia, PA 19141-3098.
2 Present address: Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104.
3 Department of Surgery, Division of Transplant Surgery, Albert Einstein Medical Center, Philadelphia, PA.


Figure 1
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Fig. 1 —Flowchart shows outcomes of adult liver transplant recipients who developed early (< 1 week after transplantation) hepatic artery thrombosis.

 

Figure 2
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Fig. 2A —52-year-old woman with hepatic artery thrombosis detected on routine sonography 6 hours after liver transplantation. Color and pulsed Doppler sonography at porta hepatis show lack of flow in hepatic artery.

 

Figure 3
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Fig. 2B —52-year-old woman with hepatic artery thrombosis detected on routine sonography 6 hours after liver transplantation. Angiogram obtained after celiac artery injection confirms hepatic artery thrombosis detected at sonography.

 

Figure 4
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Fig. 2C —52-year-old woman with hepatic artery thrombosis detected on routine sonography 6 hours after liver transplantation. Color and pulsed Doppler sonography show normal hepatic artery (HA) flow after emergency surgical thrombectomy had been performed.

 

Figure 5
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Fig. 2D —52-year-old woman with hepatic artery thrombosis detected on routine sonography 6 hours after liver transplantation. CT scan obtained 1 month after transplantation shows chronic infarction of left lobe of liver and normal right lobe. Patient eventually died of unrelated cause.

 

Figure 6
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Fig. 3 —Flowchart shows outcomes of adult liver transplant recipients who developed late (> 1 week after transplantation) hepatic artery stenosis.

 

Figure 7
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Fig. 4A —61-year-old woman with biliary dilatation requiring a stent 24 months after liver transplantation developed hepatic artery thrombosis; collateral arterial flow resulted in false-negative sonography. Duplex Doppler image at porta hepatis shows arterial flow with parvus-tardus pattern (delayed systolic upstroke and low normal resistive index of 0.55).

 

Figure 8
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Fig. 4B —61-year-old woman with biliary dilatation requiring a stent 24 months after liver transplantation developed hepatic artery thrombosis; collateral arterial flow resulted in false-negative sonography. Celiac axis angiogram shows complete occlusion of hepatic artery with collateral flow to liver (arrows).

 

Figure 9
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Fig. 4C —61-year-old woman with biliary dilatation requiring a stent 24 months after liver transplantation developed hepatic artery thrombosis; collateral arterial flow resulted in false-negative sonography. Superior mesenteric angiogram shows small collateral vessels to liver (arrow).

 

Figure 10
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Fig. 5 —Flowchart shows outcomes of adult liver transplant recipients with irreversible hepatic artery thrombosis.

 

Figure 11
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Fig. 6A —47-year-old man who underwent sonography because of elevated liver function test results 2.5 weeks after liver transplantation. Sonography showed hepatic artery thrombosis (true-positive finding); initial postoperative sonography was normal. Power Doppler sonography image at porta hepatis shows flow in portal vein and no flow in hepatic artery.

 

Figure 12
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Fig. 6B —47-year-old man who underwent sonography because of elevated liver function test results 2.5 weeks after liver transplantation. Sonography showed hepatic artery thrombosis (true-positive finding); initial postoperative sonography was normal. CT angiogram confirmed complete occlusion of hepatic artery (HA) (arrow), which was also depicted on angiography (not shown).

 

Figure 13
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Fig. 6C —47-year-old man who underwent sonography because of elevated liver function test results 2.5 weeks after liver transplantation. Sonography showed hepatic artery thrombosis (true-positive finding); initial postoperative sonography was normal. Subsequently, patient developed an infected biloma that required percutaneous drainage and placement of biliary stent. Color and pulsed Doppler sonograms obtained 9 months after treatment of biloma show multiple small arterial vessels at porta hepatis with normal arterial waveform and absent portal vein flow (arrows).

 

Figure 14
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Fig. 6D —47-year-old man who underwent sonography because of elevated liver function test results 2.5 weeks after liver transplantation. Sonography showed hepatic artery thrombosis (true-positive finding); initial postoperative sonography was normal. Angiogram obtained after superior mesenteric artery injection shows exuberant hepatic collaterals. Thrombosis of main portal vein was confirmed on portal venous phase.

 

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