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Adult Rhabdomyosarcoma: Cross-Sectional Imaging Findings Including Histopathologic Correlation

Steven D. Allen1, Eleanor C. Moskovic1, Cyril Fisher2 and J. Meirion Thomas3

1 Department of Imaging, Royal Marsden Hospital, Downs Rd., Sutton, Surrey, SM2 5PT, United Kingdom.
2 Department of Histopathology, Royal Marsden Hospital, London, United Kingdom.
3 Department of Surgery, Royal Marsden Hospital, London, United Kingdom.


Figure 1
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  		Fig. 1A —31-year-old woman with alveolar rhabdomyosarcoma of natal cleft. Axial T1-weighted MR image shows low-signal homogeneous mass (arrow) centered on natal cleft. This mass is inseparable anteriorly from anal canal.

 

Figure 2
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  		Fig. 1B —31-year-old woman with alveolar rhabdomyosarcoma of natal cleft. Axial T2-weighted MR image shows most cranial extent of lesion (black arrow). Enlarged lymph node (white arrow) in right groin is also visualized.

 

Figure 3
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  		Fig. 1C —31-year-old woman with alveolar rhabdomyosarcoma of natal cleft. Sagittal T2-weighted MR image again shows invasion of anal canal (arrow). This tumor is moderately heterogeneous and of intermediate to high signal.

 

Figure 4
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  		Fig. 1D —31-year-old woman with alveolar rhabdomyosarcoma of natal cleft. Photomicrograph of histologic specimen shows nests of discohesive cells in dense fibrous stroma, which is typical of alveolar rhabdomyosarcoma. (H and E, x200)

 

Figure 5
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  		Fig. 2A —51-year-old man with pleomorphic rhabdomyosarcoma of right thigh (arrows, A-C). Coronal T1-weighted MR image shows homogeneous lesion arising from right adductor compartment.

 

Figure 6
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  		Fig. 2B —51-year-old man with pleomorphic rhabdomyosarcoma of right thigh (arrows, A-C). Coronal contrast-enhanced T1-weighted MR image shows that lesion exhibits markedly heterogeneous enhancement.

 

Figure 7
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  		Fig. 2C —51-year-old man with pleomorphic rhabdomyosarcoma of right thigh (arrows, A-C). STIR image shows lesion is very high in signal and is heterogeneous.

 

Figure 8
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  		Fig. 2D —51-year-old man with pleomorphic rhabdomyosarcoma of right thigh (arrows, A-C). Photomicrograph of histologic specimen shows sheets of large atypical cells with abundant cytoplasm and frequent mitoses, findings that are typical of pleomorphic rhabdomyosarcoma. (H and E, x200)

 

Figure 9
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  		Fig. 3A —43-year-old man with embryonal rhabdomyosarcoma of right maxilla. Axial CT image shows enhancing, homogeneous, ill-defined mass (arrow) within right maxilla passing into right infratemporal fossa.

 

Figure 10
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  		Fig. 3B —43-year-old man with embryonal rhabdomyosarcoma of right maxilla. Coronal CT image obtained using bone window settings shows tumor has completely destroyed lateral right maxilla (arrow).

 

Figure 11
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  		Fig. 3C —43-year-old man with embryonal rhabdomyosarcoma of right maxilla. Axial CT image at level of thyroid gland shows markedly enlarged level VI lymph node (arrow).

 

Figure 12
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  		Fig. 3D —43-year-old man with embryonal rhabdomyosarcoma of right maxilla. Photomicrograph of histologic specimen shows cords of spindle-shaped and oval cells in myxoid stroma, which is typical of embryonal rhabdomyosarcoma. (H and E, x200)

 

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