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Diffusion Tensor Imaging Assessment of Brain White Matter Maturation During the First Postnatal Year

¹ Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710.
² Beaconbioscience, Doylestown, PA.
³ Department of Community and Family Medicine, Duke University Medical Center, Durham, NC.

View larger version (101K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1A —Healthy 24-week-old girl born at 40 weeks of gestational age. T2-weighted MR image at level of internal capsule shows normal appearance of brain.

View larger version (73K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1B —Healthy 24-week-old girl born at 40 weeks of gestational age. Diffusion-weighted image at level of A shows region of interest (ROI) placement in posterior limbs of internal capsules.

View larger version (76K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1C —Healthy 24-week-old girl born at 40 weeks of gestational age. Apparent diffusion coefficient (ADC) map at level corresponding to B shows ROIs in posterior limbs of internal capsules. Mean ADC was 0.82 x 10-3 mm2/s.

View larger version (76K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1D —Healthy 24-week-old girl born at 40 weeks of gestational age. Diffusion-weighted image slightly cephalic to C shows ROI placement in genu and splenium of corpus callosum.

View larger version (77K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1E —Healthy 24-week-old girl born at 40 weeks of gestational age. ADC map at level corresponding to D shows ROIs placed in genu and splenium of corpus callosum. Mean ADC in genu is 1.03 x 10-3 mm2/s and in splenium is 0.92 x 10-3 mm2/s.

View larger version (71K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1F —Healthy 24-week-old girl born at 40 weeks of gestational age. Diffusion tensor image shows ROI placement in posterior limb of internal capsules and genu and splenium of corpus callosum.

View larger version (96K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1G —Healthy 24-week-old girl born at 40 weeks of gestational age. Fractional anisotropy (FA) map at level corresponding to E shows ROIs placed in posterior limb of internal capsule and genu and splenium of corpus callosum. Mean FA value in posterior limb of internal capsule is 0.492, in genu is 0.514, and in splenium is 0.489.

View larger version (104K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1H —Healthy 24-week-old girl born at 40 weeks of gestational age. T2-weighted MR image at level of subcortical white matter shows normal appearance of brain.

View larger version (72K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1I —Healthy 24-week-old girl born at 40 weeks of gestational age. Diffusion-weighted image at level corresponding to H shows ROI placement in frontal subcortical white matter and parietal subcortical white matter.

View larger version (67K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1J —Healthy 24-week-old girl born at 40 weeks of gestational age. ADC map at level corresponding to I shows ROI placement. Mean ADC in frontal subcortical white matter is 1.05 x 10-3 mm2/s and in parietal subcortical white matter is 1.07 x 10-3 mm2/s.

View larger version (68K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1K —Healthy 24-week-old girl born at 40 weeks of gestational age. Diffusion tensor image shows ROI placement in frontal subcortical white matter and parietal subcortical white matter.

View larger version (81K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1L —Healthy 24-week-old girl born at 40 weeks of gestational age. FA map at level corresponding to K shows ROI placement. Mean FA value in frontal subcortical white matter is 0.249 and in parietal subcortical white matter is 0.233.

View larger version (8K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2 —Graph shows apparent diffusion coefficients (ADCs) for peripheral and deep white matter throughout first year of life. Each symbol represents mean deep () and peripheral () white matter values for one subject. Figure 1A, 1B, 1C, 1D, 1E, 1F, 1G, 1H, 1I, 1J, 1K, 1L shows regions of interest in representative subject. At right of each graph are adult mean ± standard error of the mean. Values were fit by broken-line linear regression functions with break points at 100 days. Increased rates of change in ADC in first 3 months are indicated by steeper slopes of initial linear fits compared with second fitted regression lines. Age normalized to term.

View larger version (9K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 3 —Graph shows fractional anisotropy (FA) for peripheral and deep white matter throughout first year of life. Each symbol represents mean peripheral () or deep () white matter FA values for one subject. At right of each graph are adult mean ± standard error of the mean. For each data set, values were fit by broken-line linear regression functions with break points at 100 days. As with apparent diffusion coefficient (Fig. 2), rates of change in FA were greater in the first 3 months compared with the rest of the year, as indicated by steeper slopes of initial linear fits compared with second fitted regression lines.

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