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Assessment of Musculoskeletal Infection in Rats to Determine Usefulness of SPIO-Enhanced MRI

¹ Department of Radiology, Bundang CHA General Hospital, College of Medicine, Pochon CHA University, Kyonggi-do 463-712, Korea.
² Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Poongnap-dong, Songpa-gu, Seoul 138-736, Korea.
³ Department of Pathology, Bundang CHA General Hospital, College of Medicine, Pochon CHA University, Kyonggi-do 463-712, Korea.
⁴ Department of Radiology, College of Medicine, Ewha Womans University, Seoul 158-710, Korea.

View larger version (142K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1A —Soft-tissue abscess in calf muscle of rat number 7. Unenhanced T2-weighted image shows inflammatory mass in calf muscle (arrows).

View larger version (158K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1B —Soft-tissue abscess in calf muscle of rat number 7. Signal-to-noise ratio (SNR) value of abscess wall (arrows) is decreased on superparamagnetic iron oxide (SPIO)-enhanced T2-weighted image (SNR change = -57.01).

View larger version (116K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1C —Soft-tissue abscess in calf muscle of rat number 7. On section stained with Prussian blue (x400), iron-loaded cells (arrows) are seen (total number = 32).

View larger version (99K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1D —Soft-tissue abscess in calf muscle of rat number 7. On section stained with CD68 (x400), macrophages (arrows) are seen (total number = 73).

View larger version (132K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2A —Joint effusion of knee in rat number 7. On unenhanced T2-weighted image, effusion is seen in knee joint (arrow).

View larger version (150K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2B —Joint effusion of knee in rat number 7. However, signal-to-noise ratio (SNR) change of synovium (arrow) is not significant on high-dose superparamagnetic iron oxide (SPIO)-enhanced T2-weighted image. Extremely low signal intensity of bone marrow caused by massive uptake of iron oxides is shown in tibia and femur.

View larger version (116K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2C —Joint effusion of knee in rat number 7. H and E-stained section shows synovial hypertrophy is minimal (arrows). (x200)

View larger version (111K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2D —Joint effusion of knee in rat number 7. On Prussian blue-stained section, iron-loaded cells are not seen. (x 200)

View larger version (123K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 3A —Soft-tissue abscess in suprapatellar area of rat number 6. Signal-to-noise ratio (SNR) value of abscess wall (arrows) on superparamagnetic iron oxide (SPIO)-enhanced T2-weighted image (B) is decreased compared with that (arrows) on unenhanced T2-weighted image (A) (SNR change = -16.44).

View larger version (116K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 3B —Soft-tissue abscess in suprapatellar area of rat number 6. Signal-to-noise ratio (SNR) value of abscess wall (arrows) on superparamagnetic iron oxide (SPIO)-enhanced T2-weighted image (B) is decreased compared with that (arrows) on unenhanced T2-weighted image (A) (SNR change = -16.44).

View larger version (145K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 3C —Soft-tissue abscess in suprapatellar area of rat number 6. Prussian blue-stained section shows iron-loaded cells (arrow) (total number = 29). (x400)

View larger version (163K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 3D —Soft-tissue abscess in suprapatellar area of rat number 6. CD68-stained section shows macrophages (arrows) (total number = 47). (x400)

View larger version (115K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 4A —Soft-tissue abscess wall of rat number 8. Section stained with Prussian blue (x400) shows uptake of iron particles in fibroblasts (solid arrow) and in macrophages (open arrows).

View larger version (147K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 4B —Soft-tissue abscess wall of rat number 8. Macrophages (arrows) can be confirmed on section stained with CD68 (x400). Nonspecific stain of plasma cells and neutrophils is also seen.

View larger version (152K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 4C —Soft-tissue abscess wall of rat number 8. On section stained with H and E (x400), fibroblasts (arrows) can be confirmed.

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