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31P MR Spectroscopy in Assessment of Response to Antiviral Therapy for Hepatitis C Virus–Related Liver Disease

Adrian K. P. Lim1, Nayna Patel1,2, Gavin Hamilton1,2, Kailash Mylvahan1,2, Yu-Ting Kuo1,3, Robert D. Goldin4 and Simon D. Taylor-Robinson1,2

1 Department of Imaging Sciences, Faculty of Medicine, Imperial College London, Robert Steiner MRI Unit, MRC Clinical Sciences Centre, Hammersmith Hospital, Du Cane Rd., London W12 0HS, United Kingdom.
2 Liver Unit, Division of Medicine, Imperial College London, St. Mary's Hospital, London, United Kingdom.
3 Department of Medical Imaging, Faculty of Medicine, School of Medicine, Kaohsiung Medical University, Taiwan.
4 Department of Histopathology, Faculty of Medicine, Imperial College London, St. Mary's Hospital, London, United Kingdom.


Figure 1
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  		Fig. 1 —40-year-old woman with cirrhosis secondary to hepatitis C virus infection. Graph shows change in 31P MR spectra 1 year after treatment. Patient successfully cleared virus after antiviral treatment. Red indicates baseline spectrum; blue, spectrum 12 months after treatment. PME = phosphomonoester, PDE = phosphodiester.

 

Figure 2
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  		Fig. 2 —Graph shows significant decrease in mean phosphomonoester/phosphodiester (PME/PDE) ratio for group of responders. SE = standard error.

 

Figure 3
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  		Fig. 3 —Graph shows nonresponders had no difference in phosphomonoester/phosphodiester (PME/PDE) ratios before and after treatment. SE = standard error.

 

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