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Quantification and Detectability of In-Stent Stenosis with CT Angiography and MR Angiography in Arterial Stents In Vitro

Melanie B. Blum1, Maria Schmook, Rüdiger Schernthaner, Gundula Edelhauser, Stefan Puchner, Johannes Lammer and Martin A. Funovics

1 All authors: Division of Angiography and Interventional Radiology, Department of Radiology, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.


Figure 1
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Fig. 1 Schema of stent phantom. a = unstented stenosis, b = in-stent stenosis, c = stented unstenosed vessel part.

 

Figure 2
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Fig. 2A Vessel phantoms with 75% or 95% stenosis at CT angiography and MR angiography. Bars represent attenuation of residual lumen (y-axis) and subjective scores of visibility of residual lumen (light gray indicates low subjective score; dark gray, high subjective score) inside respective stents (x-axis) compared with attenuation of stenosis without stent. Inserts show images with stenosis inside respective stent type. 1 = nitinol with 1.7-mm2 mesh size and 165-µm strut thickness (Expander, Bolton Medical), 2 = nitinol with 3-mm2 mesh size and 170-µm strut thickness (Hemobahn, Prograft Medical), 3 = nitinol with 4.5-mm2 mesh size and 245-µm strut thickness (SelfX, Abbott Laboratories), 4 = nitinol with 2-mm2 mesh size and 200-µm strut thickness (SMART, Cordis), 5 = nitinol with 15-mm2 mesh size and 235-µm strut thickness (Symphony, Boston Scientific), 6 = cobalt alloy with 1.7-mm2 mesh size and 195-µm strut thickness (Wallstent, Boston Scientific), 7 = standard, SE = standard error. Graph shows results for CT angiography of 75% stenosis.

 

Figure 3
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Fig. 2B Vessel phantoms with 75% or 95% stenosis at CT angiography and MR angiography. Bars represent attenuation of residual lumen (y-axis) and subjective scores of visibility of residual lumen (light gray indicates low subjective score; dark gray, high subjective score) inside respective stents (x-axis) compared with attenuation of stenosis without stent. Inserts show images with stenosis inside respective stent type. 1 = nitinol with 1.7-mm2 mesh size and 165-µm strut thickness (Expander, Bolton Medical), 2 = nitinol with 3-mm2 mesh size and 170-µm strut thickness (Hemobahn, Prograft Medical), 3 = nitinol with 4.5-mm2 mesh size and 245-µm strut thickness (SelfX, Abbott Laboratories), 4 = nitinol with 2-mm2 mesh size and 200-µm strut thickness (SMART, Cordis), 5 = nitinol with 15-mm2 mesh size and 235-µm strut thickness (Symphony, Boston Scientific), 6 = cobalt alloy with 1.7-mm2 mesh size and 195-µm strut thickness (Wallstent, Boston Scientific), 7 = standard, SE = standard error. Graph shows results for CT angiography of 95% stenosis.

 

Figure 4
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Fig. 2C Vessel phantoms with 75% or 95% stenosis at CT angiography and MR angiography. Bars represent attenuation of residual lumen (y-axis) and subjective scores of visibility of residual lumen (light gray indicates low subjective score; dark gray, high subjective score) inside respective stents (x-axis) compared with attenuation of stenosis without stent. Inserts show images with stenosis inside respective stent type. 1 = nitinol with 1.7-mm2 mesh size and 165-µm strut thickness (Expander, Bolton Medical), 2 = nitinol with 3-mm2 mesh size and 170-µm strut thickness (Hemobahn, Prograft Medical), 3 = nitinol with 4.5-mm2 mesh size and 245-µm strut thickness (SelfX, Abbott Laboratories), 4 = nitinol with 2-mm2 mesh size and 200-µm strut thickness (SMART, Cordis), 5 = nitinol with 15-mm2 mesh size and 235-µm strut thickness (Symphony, Boston Scientific), 6 = cobalt alloy with 1.7-mm2 mesh size and 195-µm strut thickness (Wallstent, Boston Scientific), 7 = standard, SE = standard error. Graph shows results for MR angiography of 75% stenosis.

 

Figure 5
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Fig. 2D Vessel phantoms with 75% or 95% stenosis at CT angiography and MR angiography. Bars represent attenuation of residual lumen (y-axis) and subjective scores of visibility of residual lumen (light gray indicates low subjective score; dark gray, high subjective score) inside respective stents (x-axis) compared with attenuation of stenosis without stent. Inserts show images with stenosis inside respective stent type. 1 = nitinol with 1.7-mm2 mesh size and 165-µm strut thickness (Expander, Bolton Medical), 2 = nitinol with 3-mm2 mesh size and 170-µm strut thickness (Hemobahn, Prograft Medical), 3 = nitinol with 4.5-mm2 mesh size and 245-µm strut thickness (SelfX, Abbott Laboratories), 4 = nitinol with 2-mm2 mesh size and 200-µm strut thickness (SMART, Cordis), 5 = nitinol with 15-mm2 mesh size and 235-µm strut thickness (Symphony, Boston Scientific), 6 = cobalt alloy with 1.7-mm2 mesh size and 195-µm strut thickness (Wallstent, Boston Scientific), 7 = standard, SE = standard error. Graph shows results for MR angiography of 95% stenosis.

 

Figure 6
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Fig. 3A Graphs show stent-related relative attenuation or signal intensity in vessel phantoms without stenosis. 1 = nitinol with 1.7-mm2 mesh size and 165-µm strut thickness (Expander, Bolton Medical), 2 = nitinol with 3-mm2 mesh size and 170-µm strut thickness (Hemobahn, Prograft Medical), 3 = nitinol with 4.5-mm2 mesh size and 245-µm strut thickness (SelfX, Abbott Laboratories), 4 = nitinol with 2-mm2 mesh size and 200-µm strut thickness (SMART, Cordis), 5 = nitinol with 15-mm2 mesh size and 235-µm strut thickness (Symphony, Boston Scientific), 6 = cobalt alloy with 1.7-mm2 mesh size and 195-µm strut thickness (Wallstent, Boston Scientific). Graph shows results for CT angiography of 95% stenosis.

 

Figure 7
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Fig. 3B Graphs show stent-related relative attenuation or signal intensity in vessel phantoms without stenosis. 1 = nitinol with 1.7-mm2 mesh size and 165-µm strut thickness (Expander, Bolton Medical), 2 = nitinol with 3-mm2 mesh size and 170-µm strut thickness (Hemobahn, Prograft Medical), 3 = nitinol with 4.5-mm2 mesh size and 245-µm strut thickness (SelfX, Abbott Laboratories), 4 = nitinol with 2-mm2 mesh size and 200-µm strut thickness (SMART, Cordis), 5 = nitinol with 15-mm2 mesh size and 235-µm strut thickness (Symphony, Boston Scientific), 6 = cobalt alloy with 1.7-mm2 mesh size and 195-µm strut thickness (Wallstent, Boston Scientific). Graph shows results for MR angiography of 95% stenosis.

 

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