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Imaging Differences in Metaplastic and Invasive Ductal Carcinomas of the Breast

Wei Tse Yang1, Bryan Hennessy2, Kristine Broglio3, Chadwick Mills1,4, Nour Sneige5, W. Grant Davis5,6, Vicente Valero7, Kelly K. Hunt8 and Michael Z. Gilcrease5

1 Department of Diagnostic Imaging, The University of Texas M. D. Anderson Cancer Center, PO Box 301439, Unit 1350, Houston, TX 77230.
2 Department of Gynecology Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX.
3 Quantitative Sciences Division, The University of Texas M. D. Anderson Cancer Center, Houston, TX.
4 Present address: Department of Radiology, Baylor College of Medicine, Houston, TX.
5 Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX.
6 Present address: Physicians Reference Laboratory, Overland Park, KS.
7 Department of Breast Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX.
8 Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX.


Figure 1
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Fig. 1 Right mediolateral oblique mammogram shows lobular mass with internal coarse calcifications (arrows) in 66-year-old woman who presented with palpable mass. Final pathology showed invasive metaplastic carcinoma with malignant chondroosseous neoplasm.

 

Figure 2
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Fig. 2A 54-year-old woman with palpable mass. Craniocaudad right mammogram shows high-density round mass with partially indistinct margins (long arrows) and partially circumscribed margins (short arrows).

 

Figure 3
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Fig. 2B 54-year-old woman with palpable mass. Transverse sonogram shows oval mixed solid and cystic mass (long arrow) with partially indistinct margins showing posterior acoustic enhancement (short arrows). Final pathology revealed spindle cell carcinoma most consistent with sarcomatoid metaplastic carcinoma.

 

Figure 4
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Fig. 3A 55-year-old woman with palpable mass. Left mediolateral oblique mammogram shows oval high-density mass with circumscribed margins (arrow).

 

Figure 5
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Fig. 3B 55-year-old woman with palpable mass. Transverse sonogram of same breast shows solid oval mass with microlobulated margins (long arrow) and posterior acoustic enhancement (short arrows). Final pathology showed high-grade invasive sarcomatoid carcinoma.

 

Figure 6
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Fig. 4A 52-year-old woman with palpable mass in left breast. Left mediolateral oblique mammogram shows high-density lobular mass (long arrows) with associated left axillary adenopathy (short arrows).

 

Figure 7
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Fig. 4B 52-year-old woman with palpable mass in left breast. Color Doppler transverse sonogram shows lobular circumscribed solid hypoechoic and hypervascular mass (arrows). Final pathology revealed high-grade invasive squamous cell carcinoma.

 

Figure 8
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Fig. 5A 63-year-old woman with palpable mass in left breast. Left craniocaudad mammogram shows high-density round mass with partially spiculated margins (arrows). Overlying marker denotes palpable mass.

 

Figure 9
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Fig. 5B 63-year-old woman with palpable mass in left breast. Transverse sonogram shows irregular mixed solid and cystic mass (long arrow) with mild posterior acoustic enhancement (short arrows). Final pathology revealed sarcomatoid carcinoma with osseous metaplasia.

 

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