Imaging Differences in Metaplastic and Invasive Ductal Carcinomas of the Breast
Wei Tse Yang1,
Bryan Hennessy2,
Kristine Broglio3,
Chadwick Mills1,4,
Nour Sneige5,
W. Grant Davis5,6,
Vicente Valero7,
Kelly K. Hunt8 and
Michael Z. Gilcrease5
1 Department of Diagnostic Imaging, The University of Texas M. D. Anderson
Cancer Center, PO Box 301439, Unit 1350, Houston, TX 77230.
2 Department of Gynecology Medical Oncology, The University of Texas M. D.
Anderson Cancer Center, Houston, TX.
3 Quantitative Sciences Division, The University of Texas M. D. Anderson Cancer
Center, Houston, TX.
4 Present address: Department of Radiology, Baylor College of Medicine, Houston,
TX.
5 Department of Pathology, The University of Texas M. D. Anderson Cancer Center,
Houston, TX.
6 Present address: Physicians Reference Laboratory, Overland Park, KS.
7 Department of Breast Medical Oncology, The University of Texas M. D. Anderson
Cancer Center, Houston, TX.
8 Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer
Center, Houston, TX.

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Fig. 1 —Right mediolateral oblique mammogram shows lobular mass with
internal coarse calcifications (arrows) in 66-year-old woman who
presented with palpable mass. Final pathology showed invasive metaplastic
carcinoma with malignant chondroosseous neoplasm.
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Fig. 2A —54-year-old woman with palpable mass. Craniocaudad right
mammogram shows high-density round mass with partially indistinct margins
(long arrows) and partially circumscribed margins (short
arrows).
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Fig. 2B —54-year-old woman with palpable mass. Transverse sonogram
shows oval mixed solid and cystic mass (long arrow) with partially
indistinct margins showing posterior acoustic enhancement (short
arrows). Final pathology revealed spindle cell carcinoma most consistent
with sarcomatoid metaplastic carcinoma.
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Fig. 3B —55-year-old woman with palpable mass. Transverse sonogram of
same breast shows solid oval mass with microlobulated margins (long
arrow) and posterior acoustic enhancement (short arrows). Final
pathology showed high-grade invasive sarcomatoid carcinoma.
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Fig. 4A —52-year-old woman with palpable mass in left breast. Left
mediolateral oblique mammogram shows high-density lobular mass (long
arrows) with associated left axillary adenopathy (short
arrows).
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Fig. 4B —52-year-old woman with palpable mass in left breast. Color
Doppler transverse sonogram shows lobular circumscribed solid hypoechoic and
hypervascular mass (arrows). Final pathology revealed high-grade
invasive squamous cell carcinoma.
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Fig. 5A —63-year-old woman with palpable mass in left breast. Left
craniocaudad mammogram shows high-density round mass with partially spiculated
margins (arrows). Overlying marker denotes palpable mass.
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Fig. 5B —63-year-old woman with palpable mass in left breast.
Transverse sonogram shows irregular mixed solid and cystic mass (long
arrow) with mild posterior acoustic enhancement (short arrows).
Final pathology revealed sarcomatoid carcinoma with osseous metaplasia.
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Copyright © 2007 by the American Roentgen Ray Society.