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Dedicated Cone-Beam Breast CT: Feasibility Study with Surgical Mastectomy Specimens

Wei Tse Yang1, Selin Carkaci1, Lingyun Chen2, Chao-Jen Lai2, Aysegul Sahin3, Gary J. Whitman1 and Chris C. Shaw2

1 Department of Diagnostic Radiology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1350, Houston, TX 77030.
2 Department of Imaging Physics, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030.
3 Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030.


Figure 1
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  		Fig. 1A —Drawings show flat-panel detector-based cone-beam CT system. Patient lies prone with one breast drawn downward through opening in scanning device.

 

Figure 2
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  		Fig. 1B —Drawings show flat-panel detector-based cone-beam CT system. X-ray tube and detector are mounted on rotating gantry and rotated around breast during acquisition.

 

Figure 3
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  		Fig. 2A —51-year-old woman with invasive ductal cancer. Cone-beam breast CT image shows metallic artifacts caused by stereotactic clip within breast (arrow).

 

Figure 4
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  		Fig. 2B —51-year-old woman with invasive ductal cancer. No metallic artifacts after modified algorithm to correct beam hardening.

 

Figure 5
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  		Fig. 3A —51-year-old woman with invasive ductal carcinoma of left breast occupying area of 6 x 5 cm. Coronal (A) and axial (B) CT scans of left breast show irregular mass with spiculated margins (arrows).

 

Figure 6
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  		Fig. 3B —51-year-old woman with invasive ductal carcinoma of left breast occupying area of 6 x 5 cm. Coronal (A) and axial (B) CT scans of left breast show irregular mass with spiculated margins (arrows).

 

Figure 7
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  		Fig. 3C —51-year-old woman with invasive ductal carcinoma of left breast occupying area of 6 x 5 cm. Transverse sonogram shows irregular solid hypoechoic mass in left retroareolar position with angular margins and dense posterior acoustic shadowing (arrowheads).

 

Figure 8
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  		Fig. 4 —63-year-old woman with invasive ductal carcinoma of left breast. Coronal CT image shows microcalcifications within area of architectural distortion representing known cancer (arrows). Pathology showed ductal carcinoma in situ associated with microcalcifications.

 

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