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Silicoproteinosis: High-Resolution CT Findings in 13 Patients

Edson Marchiori1, Carolina Althoff Souza2, Tatiana Gontijo Barbassa1, Dante L. Escuissato3, Emerson L. Gasparetto1 and Arthur Soares Souza, Jr.4

1 Department of Radiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
2 Department of Diagnostic Imaging, The Ottawa Hospital, 501 Smyth Rd., Ottawa, ON, Canada K1H 8L6.
3 Department of Radiology, Federal University of Parana, Curitiba, Brazil.
4 Department of Radiology, Faculty of Medicine of São José do Rio Preto, São José do Rio Preto, Brazil.


Figure 1
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  		Fig. 1 —Photomicrograph of autopsy specimen from male cadaver (age at death, 28 years; cause of death, silicoproteinosis) shows abundant intraalveolar proteinaceous material and positive reaction to stain. (Periodic acid–Schiff, x100)

 

Figure 2
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  		Fig. 2A —21-year-old man with silicoproteinosis. High-resolution CT scan shows air-space consolidation (arrowhead) within superior segment of right lower lobe and innumerable ill-defined centrilobular nodules. Confluent nodules (arrows) are present in upper lobes.

 

Figure 3
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  		Fig. 2B —21-year-old man with silicoproteinosis. Unenhanced CT scan obtained at mediastinal window settings shows consolidation involving predominantly dependent portions of lungs. Foci of calcification (arrows) are present within area of consolidation. Small bilateral pleural effusions and calcified mediastinal lymph node (arrowhead) are evident.

 

Figure 4
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  		Fig. 3A —29-year-old man with silicoproteinosis. High-resolution CT scan shows innumerable bilateral centrilobular nodules, some of them confluent. Punctate calcification is present within area of consolidation (arrow) in right upper lobe. Mild dilatation of trachea is evident.

 

Figure 5
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  		Fig. 3B —29-year-old man with silicoproteinosis. High-resolution CT scan obtained at lower level than A shows multiple air-space nodules. Some of these nodules are poorly defined and have ground-glass attenuation (thin arrows). Calcified mediastinal and hilar nodes (thick arrows) are evident.

 

Figure 6
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  		Fig. 4 —44-year-old man with silicoproteinosis. High-resolution CT scan shows patchy bilateral ground-glass opacities and multiple ill-defined centrilobular nodules (arrows).

 

Figure 7
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  		Fig. 5A —27-year-old man with silicoproteinosis. High-resolution CT scan shows air-space consolidation with air bronchograms in right upper lobe and multiple bilateral centrilobular nodules (arrows). Mild dilatation of trachea is evident.

 

Figure 8
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  		Fig. 5B —27-year-old man with silicoproteinosis. High-resolution CT scan obtained at lower level than A shows multiple centrilobular nodules (arrows), some of them confluent.

 

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