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Measurement of Serum Calcium Concentration After Administration of Four Gadolinium-Based Contrast Agents to Human Volunteers

Jeffery J. Brown1, Michael R. Hynes2 and James H. Wible, Jr.2

1 Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO.
2 Covidien/Mallinckrodt Imaging, PO Box 5840, 675 McDonnell Blvd., Saint Louis, MO 63134.


Figure 1
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Fig. 1 Effects of gadoversetamide (0.1 mmol/kg) on measurement of serum calcium. Values represent mean and standard error of mean (n = 12). Asterisks denote statistically significant (p < 0.05) differences from baseline. Diamonds indicate orthocresolphthalein; squares, arsenazo III; circles, inductively coupled plasma mass spectrometry.

 

Figure 2
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Fig. 2 Effects of gadodiamide (0.1 mmol/kg) on measurement of serum calcium. Values represent mean and standard error of mean (n = 12). Asterisks denote statistically significant (p < 0.05) differences from baseline. Diamonds indicate orthocresolphthalein; squares, arsenazo III; circles, inductively coupled plasma mass spectrometry.

 

Figure 3
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Fig. 3A Effects of gadopentetate and gadoteridol on measurement of serum calcium. Values represent mean and standard error of mean (n = 12). Diamonds indicate orthocresolphthalein; squares, arsenazo III; circles, inductively coupled plasma mass spectrometry. Gadopentetate 0.1 mmol/kg.

 

Figure 4
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Fig. 3B Effects of gadopentetate and gadoteridol on measurement of serum calcium. Values represent mean and standard error of mean (n = 12). Diamonds indicate orthocresolphthalein; squares, arsenazo III; circles, inductively coupled plasma mass spectrometry. Gadoteridol 0.1 mmol/kg.

 

Figure 5
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Fig. 4 Mean serum concentration of gadolinium versus time. Values represent mean (n = 12). No statistical differences occurred between different gadolinium chelates. Diamonds indicate gadodiamide; squares, gadopentetate; circles, gadoversetamide; triangles, gadoteridol.

 

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