Safety and Efficacy of Gadofosveset-Enhanced MR Angiography for Evaluation of Pedal Arterial Disease: Multicenter Comparative Phase 3 Study
Enrique Bosch1,
Karl-Friedrich Kreitner2,
Mario Fava Peirano3,
Siegfried Thurner4,
Kohkan Shamsi5,6 and
Edward C. Parsons, Jr.7
1 Hospital Clinica Alemana, Santiago, Chile.
2 Klinik und Poliklinik fur Radiologie der Johannes-Gutenberg-Universität
Mainz, Mainz, Germany.
3 Hospital Clinico de la Universidad Catolica, Servicio Radiologia, Santiago,
Chile.
4 Krankenhaus der Barmherziegen Bruder, Universität Wien, Vienna,
Austria.
5 Bayer HealthCare, Montville, New Jersey, 07045.
6 Present address: Symbiotic Pharma Research, Pine Brook, NJ.
7 EPIX Pharmaceuticals, 4 Maguire Rd., Lexington, MA 02421.

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Fig. 1A —Receiver operating characteristic (ROC) curves. Open triangles
indicate reader A, unenhanced images; solid triangles, reader A,
contrast-enhanced images; open squares, reader B, unenhanced images; solid
squares, reader B, contrast-enhanced images; open circles, reader C,
unenhanced images; solid circles, reader C, contrast-enhanced images. Graph
shows ROC curves for 0.03-mmol/kg dose group.
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Fig. 1B —Receiver operating characteristic (ROC) curves. Open triangles
indicate reader A, unenhanced images; solid triangles, reader A,
contrast-enhanced images; open squares, reader B, unenhanced images; solid
squares, reader B, contrast-enhanced images; open circles, reader C,
unenhanced images; solid circles, reader C, contrast-enhanced images. Graph
shows ROC curves for 0.05-mmol/kg dose group.
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Fig. 2A —49-year-old man with left-sided claudication and gangrenous left
great toe. Angiogram (A) and maximum intensity projections from
unenhanced 2D time-of-flight MR angiogram (B) and gadofosveset-enhanced
MR angiograms in dynamic (C) and steady (D) states show
comparable findings.
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Fig. 2B —49-year-old man with left-sided claudication and gangrenous left
great toe. Angiogram (A) and maximum intensity projections from
unenhanced 2D time-of-flight MR angiogram (B) and gadofosveset-enhanced
MR angiograms in dynamic (C) and steady (D) states show
comparable findings.
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Fig. 2C —49-year-old man with left-sided claudication and gangrenous left
great toe. Angiogram (A) and maximum intensity projections from
unenhanced 2D time-of-flight MR angiogram (B) and gadofosveset-enhanced
MR angiograms in dynamic (C) and steady (D) states show
comparable findings.
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Fig. 2D —49-year-old man with left-sided claudication and gangrenous left
great toe. Angiogram (A) and maximum intensity projections from
unenhanced 2D time-of-flight MR angiogram (B) and gadofosveset-enhanced
MR angiograms in dynamic (C) and steady (D) states show
comparable findings.
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Copyright © 2008 by the American Roentgen Ray Society.