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High-Intensity Focused Ultrasound: Current Potential and Oncologic Applications

Theodore J. Dubinsky1, Carlos Cuevas, Manjiri K. Dighe, Orpheus Kolokythas and Joo Ha Hwang

1 All authors: Department of Radiology, University of Washington, Box 359728, 325 Ninth Ave., Seattle, WA 98104.


Figure 1
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  		Fig. 1 —High-intensity focused ultrasound lesion formation in polyacrylamide hydrogel containing bovine serum albumin that becomes optically opaque when denatured. Treatment site is roughly 9 mm long by 3 mm wide.

 

Figure 2
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  		Fig. 2 —Illustration depicts extracorporeal high-intensity focused ultrasound therapy of intraabdominal tumor.

 

Figure 3
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  		Fig. 3A —Ex vivo porcine liver treated with high-intensity focused ultrasound (HIFU). Transducer is above liver and energy is propagated down. Thermocouple is placed in focal region to measure temperature during HIFU exposure (arrow).

 

Figure 4
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  		Fig. 3B —Ex vivo porcine liver treated with high-intensity focused ultrasound (HIFU). B-mode sonogram corresponding to sample in A. Hyperechoic area (arrow) corresponds to damaged tissue. Hyperecho is due to gas bubble formation from tissue boiling in targeted region.

 

Figure 5
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  		Fig. 3C —Ex vivo porcine liver treated with high-intensity focused ultrasound (HIFU). Histology from ex vivo porcine liver treated with HIFU (cross-section of single HIFU lesion) shows central region of coagulation necrosis. (H and E).

 

Figure 6
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  		Fig. 3D —Ex vivo porcine liver treated with high-intensity focused ultrasound (HIFU). Corresponding viability stain shows central region of nonviable cells with margin of tissue that has some viable cells. Scale bar = 1 mm.

 

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