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Three-Point Technique of Fat Quantification of Muscle Tissue as a Marker of Disease Progression in Duchenne Muscular Dystrophy: Preliminary Study

¹ All authors: Department of Radiology, Children's Hospital Los Angeles, 4650 Sunset Blvd., MS#81, Los Angeles, CA 90027.

View larger version (124K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1A —10-year-old boy with Duchenne muscular dystrophy and 9-year-old healthy boy. T1-weighted spin-echo MR images (TR/TE, 400/10) show regions of interest on previously obtained comparison image of 9-year-old healthy boy (A) and in 10-year-old patient with functional score of 3 (B). 1 = vastus lateralis, 2 = biceps femoris, 3 = semitendinosus, 4 = vastus medialis, 5 = rectus femoris, 6 = vastus intermedius.

View larger version (157K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1B —10-year-old boy with Duchenne muscular dystrophy and 9-year-old healthy boy. T1-weighted spin-echo MR images (TR/TE, 400/10) show regions of interest on previously obtained comparison image of 9-year-old healthy boy (A) and in 10-year-old patient with functional score of 3 (B). 1 = vastus lateralis, 2 = biceps femoris, 3 = semitendinosus, 4 = vastus medialis, 5 = rectus femoris, 6 = vastus intermedius.

View larger version (126K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1C —10-year-old boy with Duchenne muscular dystrophy and 9-year-old healthy boy. MR image shows results of Dixon water measurement in patient.

View larger version (163K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1D —10-year-old boy with Duchenne muscular dystrophy and 9-year-old healthy boy. MR image shows computed percentage fat in patient.

View larger version (8K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2A —Graphs show Dixon MRI measurements of intramuscular fat percentage increased significantly with age in all muscles examined. Data points for biceps and semitendinosus for one patient were omitted because of poor magnetic field homogeneity and compromised separation of lipid and water signals. Rectus femoris muscle (y = -8.6 + 6.2 * x; r2 = 0.78; p = 0.002).

View larger version (8K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2B —Graphs show Dixon MRI measurements of intramuscular fat percentage increased significantly with age in all muscles examined. Data points for biceps and semitendinosus for one patient were omitted because of poor magnetic field homogeneity and compromised separation of lipid and water signals. Vastus lateralis muscle (y = -16.3 + 6.9 * x; r2 = 0.78; p = 0.002).

View larger version (8K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2C —Graphs show Dixon MRI measurements of intramuscular fat percentage increased significantly with age in all muscles examined. Data points for biceps and semitendinosus for one patient were omitted because of poor magnetic field homogeneity and compromised separation of lipid and water signals. Vastus intermedius muscle (y = -25.5 + 8.6 * x; r2 = 0.92; p < 0.0001).

View larger version (8K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2D —Graphs show Dixon MRI measurements of intramuscular fat percentage increased significantly with age in all muscles examined. Data points for biceps and semitendinosus for one patient were omitted because of poor magnetic field homogeneity and compromised separation of lipid and water signals. Vastus medialis muscle (y = -33.0 + 8.8 * x; r2 = 0.92; p < 0.0001).

View larger version (8K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2E —Graphs show Dixon MRI measurements of intramuscular fat percentage increased significantly with age in all muscles examined. Data points for biceps and semitendinosus for one patient were omitted because of poor magnetic field homogeneity and compromised separation of lipid and water signals. Biceps femoris muscle (y = -22.0 + 7.9 * x; r2 = 0.68; p = 0.01).

View larger version (8K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2F —Graphs show Dixon MRI measurements of intramuscular fat percentage increased significantly with age in all muscles examined. Data points for biceps and semitendinosus for one patient were omitted because of poor magnetic field homogeneity and compromised separation of lipid and water signals. Semitendinosus muscle (y = -40.9 + 9.8 * x; r2 = 0.73; p = 0.007).

View larger version (7K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 3A —Graphs show Dixon MRI measurements of intramuscular fat percentage increased significantly with decreasing functional level in all muscles examined. Graphs show rectus femoris (A), vastus lateralis (B), vastus intermedius (C), vastus medialis (D), biceps femoris (E), and semitendinosus (F) muscles.

View larger version (8K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 3B —Graphs show Dixon MRI measurements of intramuscular fat percentage increased significantly with decreasing functional level in all muscles examined. Graphs show rectus femoris (A), vastus lateralis (B), vastus intermedius (C), vastus medialis (D), biceps femoris (E), and semitendinosus (F) muscles.

View larger version (8K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 3C —Graphs show Dixon MRI measurements of intramuscular fat percentage increased significantly with decreasing functional level in all muscles examined. Graphs show rectus femoris (A), vastus lateralis (B), vastus intermedius (C), vastus medialis (D), biceps femoris (E), and semitendinosus (F) muscles.

View larger version (8K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 3D —Graphs show Dixon MRI measurements of intramuscular fat percentage increased significantly with decreasing functional level in all muscles examined. Graphs show rectus femoris (A), vastus lateralis (B), vastus intermedius (C), vastus medialis (D), biceps femoris (E), and semitendinosus (F) muscles.

View larger version (8K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 3E —Graphs show Dixon MRI measurements of intramuscular fat percentage increased significantly with decreasing functional level in all muscles examined. Graphs show rectus femoris (A), vastus lateralis (B), vastus intermedius (C), vastus medialis (D), biceps femoris (E), and semitendinosus (F) muscles.

View larger version (8K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 3F —Graphs show Dixon MRI measurements of intramuscular fat percentage increased significantly with decreasing functional level in all muscles examined. Graphs show rectus femoris (A), vastus lateralis (B), vastus intermedius (C), vastus medialis (D), biceps femoris (E), and semitendinosus (F) muscles.

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