Proton MR Spectroscopy in Normal Breasts Between Pre- and Postmenopausal Women: A Preliminary Study
Jane Wang1,2,
Pao-Ling Torng3,
Tsang-Pai Liu4,5,
Kuan-Lin Chen1 and
Tiffany Ting-Fang Shih1,2
1 Department of Radiology, National Taiwan University College of Medicine,
Taipei, Taiwan.
2 Department of Medical Imaging, National Taiwan University Hospital, 7
Chung-Shan S Rd., Taipei 100, Taiwan.
3 Department of Obstetrics and Gynecology, National Taiwan University Hospital
and National Taiwan University College of Medicine, Taipei, Taiwan.
4 Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan.
5 Department of Surgery, Mackay Medicine, Nursing, and Management College,
Taipei, Taiwan.
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Fig. 1A —41-year-old woman with presumably normal right breast.
Coronal (A) and sagittal (B) FLASH and axial images (not shown)
show cubic voxel positioning at area with most abundant fibroglandular breast
tissue. Single-voxel proton MR spectroscopy was then performed.
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Fig. 1B —41-year-old woman with presumably normal right breast.
Coronal (A) and sagittal (B) FLASH and axial images (not shown)
show cubic voxel positioning at area with most abundant fibroglandular breast
tissue. Single-voxel proton MR spectroscopy was then performed.
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Fig. 2A —Major water and lipid peaks on single-voxel proton MR
spectroscopy of breast in 45-year-old woman with presumably normal right
breast. SI = signal intensity. Graph shows that on STEAM (stimulated echo
acquisition mode) pulse sequence, there is major lipid peak contributing to
methylene resonance located at approximately 1.6 ppm (lipid 1 [L1],
arrow), and second most common lipid peak at about 2.3 ppm,
contributing to allylic methylene protons (lipid 2 [L2], arrowhead).
Water peak is located at 4.8 ppm (double thin arrows).
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Fig. 2B —Major water and lipid peaks on single-voxel proton MR
spectroscopy of breast in 45-year-old woman with presumably normal right
breast. SI = signal intensity. Graph of PRESS (point-resolved spectroscopy)
with water suppression shows lipid 1 (L1, arrow), lipid 2 (L2,
arrowhead), and water peak (double thin arrows).
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Fig. 3A —Scatter plots from multivariate regression analysis in pre-
and postmenopausal women. Only results with statistical significance
(p < 0.05) are shown. For premenopausal group, water fraction 1
(H2OF1) is positively correlated with breast density. (β [regression
coefficient] = 0.084; p = 0.018)
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Fig. 3B —Scatter plots from multivariate regression analysis in pre-
and postmenopausal women. Only results with statistical significance
(p < 0.05) are shown. For premenopausal group, lipid fraction 1
(LF1) is negatively correlated with breast density (β = –0.084;
p = 0.018)
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Fig. 3C —Scatter plots from multivariate regression analysis in pre-
and postmenopausal women. Only results with statistical significance
(p < 0.05) are shown. For postmenopausal group, lipid fraction 2
(LF2) has positive correlation with age (β = 0.006; p =
0.049)
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Fig. 4A —Scatter plots from multivariate regression analysis in total
study population. Only results with p < 0.05 are shown. Water
fraction 1 (H2OF1) (A) is positively correlated with breast density
(β [regression coefficient] = 0.059; p = 0.019), and lipid fraction 1
(B) has negative correlation with breast density (β =
–0.059; p = 0.019).
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Fig. 4B —Scatter plots from multivariate regression analysis in total
study population. Only results with p < 0.05 are shown. Water
fraction 1 (H2OF1) (A) is positively correlated with breast density
(β [regression coefficient] = 0.059; p = 0.019), and lipid fraction 1
(B) has negative correlation with breast density (β =
–0.059; p = 0.019).
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Fig. 4C —Scatter plots from multivariate regression analysis in total
study population. Only results with p < 0.05 are shown. Lipid
fraction 2 has positive correlation with hormonal status, with the
premenopausal status coded as 1 and the postmenopausal status coded as 0.
(β = 0.098; p = 0.024)
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