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Repeatability Limits for Measurement of Coronary Artery Calcified Plaque with Cardiac CT in the Multi-Ethnic Study of Atherosclerosis

Hyoju Chung1, Robyn L. McClelland1, Ronit Katz1, J. Jeffrey Carr2 and Matthew J. Budoff3

1 Department of Biostatistics, Collaborative Health Studies Coordinating Center, University of Washington, 6200 NE 74th St, Building 29, Suite 310, Seattle, WA 98115.
2 Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC.
3 Los Angeles Biomedical Research Institute at Harbor–UCLA, Torrance, CA.


Figure 1
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  		Fig. 1 —Bland-Altman scatterplot shows rescan difference versus rescan average of Agatston score in Multi-Ethnic Study of Atherosclerosis at examination 1.

 

Figure 2
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  		Fig. 2 —Scatterplot shows rescan relative difference (%) versus rescan average of Agatston score in Multi-Ethnic Study of Atherosclerosis at examination 1.

 

Figure 3
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  		Fig. 3 —Graph shows coronary artery calcification (CAC)-adjusted and CAC- and body mass index (BMI)–adjusted repeatability limits for Agatston score less than 400 at Multi-Ethnic Study of Atherosclerosis examination 1. Solid line represents CAC-adjusted repeatability limits; dashed line, CAC- and BMI-adjusted repeatability limits for BMI of 25; dotted line, CAC- and BMI-adjusted repeatability limit for BMI of 40.

 

Figure 4
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  		Fig. 4 —Plot shows percentage of follow-up Agatston score beyond baseline coronary artery calcification (CAC)–adjusted repeatability limit for 2,832 Multi-Ethnic Study of Atherosclerosis participants with positive CAC scores at baseline. Samples are grouped into 3-month intervals. Point shading and size reflect group size. Black indicates n ≥ 100; range, 129–483. Gray indicates n < 100; range, 3–43. Larger points indicate greater number of participants. Dashed line represents overall proportion (36.4%) of detectable change.

 

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