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Dynamic Oxygen-Enhanced MRI Versus Quantitative CT: Pulmonary Functional Loss Assessment and Clinical Stage Classification of Smoking-Related COPD

¹ Department of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan.
² Philips Medical Systems, Tokyo, Japan.

View larger version (108K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1A —38-year-old nonsmoking volunteer. Routine axial CT images show no low-attenuation area in either lung. Homogeneously functional lung is shown in red on axial quantitative CT (B).

View larger version (56K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1B —38-year-old nonsmoking volunteer. Routine axial CT images show no low-attenuation area in either lung. Homogeneously functional lung is shown in red on axial quantitative CT (B).

View larger version (76K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1C —38-year-old nonsmoking volunteer. Coronal wash-in time map calculated from dynamic oxygen-enhanced MR images obtained using centrically reordered inversion recovery HASTE sequence shows heterogeneous and relatively short regional wash-in time in both lungs. Mean wash-in time was 16.0 seconds.

View larger version (77K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1D —38-year-old nonsmoking volunteer. Coronal relative enhancement map calculated from same dynamic oxygen-enhanced MR data as C shows heterogeneously and relatively high relative enhancement ratio for both lungs. Mean relative enhancement ratio was 0.20.

View larger version (112K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2A —76-year-old smoking subject with Brinkman index of 1,480. Routine axial CT images show multiple low attenuation areas due to pulmonary emphysema in both lungs. Heterogeneously functional lung is shown in red and pulmonary emphysema in black on quantitative axial CT (B).

View larger version (79K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2B —76-year-old smoking subject with Brinkman index of 1,480. Routine axial CT images show multiple low attenuation areas due to pulmonary emphysema in both lungs. Heterogeneously functional lung is shown in red and pulmonary emphysema in black on quantitative axial CT (B).

View larger version (91K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2C —76-year-old smoking subject with Brinkman index of 1,480. Coronal wash-in time map calculated from dynamic oxygen-enhanced MR images obtained using centrically reordered inversion recovery HASTE sequence shows heterogeneous and markedly prolonged regional wash-in time in both lungs. Mean wash-in time was 53.0 seconds.

View larger version (74K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2D —76-year-old smoking subject with Brinkman index of 1,480. Coronal relative enhancement map calculated from same dynamic oxygen-enhanced MR data as C shows heterogeneously and markedly reduced relative enhancement ratio in both lungs. Mean relative enhancement ratio was 0.08.

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