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Combined Percutaneous Radiofrequency Ablation and Ethanol Injection for Hepatocellular Carcinoma in High-Risk Locations

Stephen N. Wong1,2, Chun-Jung Lin1, Chen-Chun Lin1, Wei-Ting Chen1, Ian Homer Y. Cua1 and Shi-Ming Lin1

1 Liver Research Unit, Department of Hepatogastroenterology, Chang Gung Memorial Hospital and Chang Gung University, 199, Tunghwa Rd., Taipei, Taiwan.
2 Section of Gastroenterology, University of Santo Tomas Hospital, Manila, Philippines.


Figure 1
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Fig. 1 Schematic shows patient and tumor distribution in analyses of outcomes. TACE = transarterial chemoembolization, HR = high risk, PEI = percutaneous ethanol injection.

 

Figure 2
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Fig. 2 Distribution of high-risk tumors. * = 44 tumors were located near both vessel/s and vital structure. PV = portal vein, HV = hepatic vein, IVC = inferior vena cava, GB = gallbladder, GIT = gastrointestinal tract.

 

Figure 3
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Fig. 3 Graph compares local tumor progression rates for three treatment groups. HR = high-risk, RF = radiofrequency, NHR = non-high-risk, PEI = percutaneous ethanol injection.

 

Figure 4
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Fig. 4A 45-year-old man with hepatitis B virus–related cirrhosis and hepatocellular carcinoma. Indistinct tumor border is independent predictor of local tumor progression. Arterial phase CT scan before radiofrequency ablation shows enhancement of solitary tumor (arrows) at segment VII.

 

Figure 5
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Fig. 4B 45-year-old man with hepatitis B virus–related cirrhosis and hepatocellular carcinoma. Indistinct tumor border is independent predictor of local tumor progression. Portal phase CT scan before radiofrequency ablation shows contrast washout (arrows) at segment VII.

 

Figure 6
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Fig. 4C 45-year-old man with hepatitis B virus–related cirrhosis and hepatocellular carcinoma. Indistinct tumor border is independent predictor of local tumor progression. Sonographic image shows indistinct tumor borders (arrows), as in A and B.

 

Figure 7
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Fig. 4D 45-year-old man with hepatitis B virus–related cirrhosis and hepatocellular carcinoma. Indistinct tumor border is independent predictor of local tumor progression. Dynamic CT scan 1 day after radiofrequency ablation shows complete ablation of area of index tumor with peripheral enhancement due to postablation hyperemia.

 

Figure 8
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Fig. 4E 45-year-old man with hepatitis B virus–related cirrhosis and hepatocellular carcinoma. Indistinct tumor border is independent predictor of local tumor progression. Repeated CT scans 2 months after D show local tumor progression at posterior border of ablation zone with enhancement (arrowhead) in arterial (E) and washout in portal (F) phases.

 

Figure 9
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Fig. 4F 45-year-old man with hepatitis B virus–related cirrhosis and hepatocellular carcinoma. Indistinct tumor border is independent predictor of local tumor progression. Repeated CT scans 2 months after D show local tumor progression at posterior border of ablation zone with enhancement (arrowhead) in arterial (E) and washout in portal (F) phases.

 

Figure 10
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Fig. 5 Graphs compare survival (left) and local tumor progression-free survival (right) rates for patient groups. HR = high-risk, NHR = non-high-risk.

 

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