Use of Perfluorocarbon Compound in the Endorectal Coil to Improve MR Spectroscopy of the Prostate
Haesun Choi1 and
Jingfei Ma2
1 Department of Diagnostic Radiology, The University of Texas M. D. Anderson
Cancer Center, 1515 Holcombe Blvd., Box Unit 368, Houston, TX 77030.
2 Department of Imaging Physics, The University of Texas M. D. Anderson Cancer
Center, Houston, TX.
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Fig. 1 —Graph shows spectral line widths for prostate MR spectroscopy
with both air and perfluorocarbon (PFC) in endorectal coils (n = 13).
Mean line width decreased from 14.8 to 7.0 Hz with PFC-filled endorectal coil
(p < 0.0001, Student's t test).
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Fig. 2 —Graph shows spectral line widths for prostate MR spectroscopy
with either air or perfluorocarbon (PFC) in endorectal coils (n =
62). Mean line width decreased from 13.3 to 7.3 Hz with PFC-filled endorectal
coil (p < 0.0001, Student's t test).
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Fig. 3A —Axial MR images of patients with line widths greater than 10
Hz on perfluorocarbon (PFC)-filled endorectal MR spectroscopy. 65-year-old man
with clinical stage T2c and Gleason score 7 adenocarcinoma of prostate, and
line width of 12 Hz. T2-weighted axial image shows small amount of rectal air
in layer anterior to PFC-filled endorectal coil (arrowheads).
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Fig. 3B —Axial MR images of patients with line widths greater than 10
Hz on perfluorocarbon (PFC)-filled endorectal MR spectroscopy. 64-year-old man
with clinical staage T1c and Gleason score 6 adenocarcinoma of prostate, and
line width of 13 Hz. T1-weighted axial image shows small amount of rectal air
in layer anterior to PFC-filled endorectal coil (arrowheads). Diffuse
hemorrhage is present throughout peripheral zone (arrow).
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Fig. 4A —50-year-old man with clinical stage T1c and Gleason score 7
adenocarcinoma of prostate and improvement in spectral resolution of MR
spectroscopy with use of perfluorocarbon (PFC)-filled endorectal coil.
T2-weighted axial image shows benign-appearing hyperintense voxel
(box) in left peripheral zone (arrows).
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Fig. 4B —50-year-old man with clinical stage T1c and Gleason score 7
adenocarcinoma of prostate and improvement in spectral resolution of MR
spectroscopy with use of perfluorocarbon (PFC)-filled endorectal coil. Graph
shows nondiagnostic quality of MR spectra from voxel in A obtained with
air-filled endorectal coil.
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Fig. 4C —50-year-old man with clinical stage T1c and Gleason score 7
adenocarcinoma of prostate and improvement in spectral resolution of MR
spectroscopy with use of perfluorocarbon (PFC)-filled endorectal coil. Graph
shows diagnostic MR spectra from repeated MR spectroscopy with PFC-filled
endorectal coil clearly resolve choline and creatine peaks and additional
polyamine peak (Po) between them. Line width decreased from 12 Hz with air to
6 Hz with PFC in endorectal coils.
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Fig. 5A —64-year-old man with clinical stage T1c adenocarcinoma of
prostate with Gleason score of 6 and improved spectral resolution of MR
spectroscopy with perfluorocarbon (PFC)-filled endorectal coil. MR spectra
from two hypointense voxels on T2-weighted axial image (A) performed
with air (B) and PFC (C) in endorectal coils show dramatic
improvement in spectral resolution with PFC. Polyamine peaks (Po) are clear in
C but not in B. Line width decreased from 16 to 6 Hz. Larger MR
spectroscopy volume box for MR spectroscopy with PFC (white,
A) than for MR spectroscopy with air (black, A) allows
inclusion of larger area of prostate tissue and anterior rectum.
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Fig. 5B —64-year-old man with clinical stage T1c adenocarcinoma of
prostate with Gleason score of 6 and improved spectral resolution of MR
spectroscopy with perfluorocarbon (PFC)-filled endorectal coil. MR spectra
from two hypointense voxels on T2-weighted axial image (A) performed
with air (B) and PFC (C) in endorectal coils show dramatic
improvement in spectral resolution with PFC. Polyamine peaks (Po) are clear in
C but not in B. Line width decreased from 16 to 6 Hz. Larger MR
spectroscopy volume box for MR spectroscopy with PFC (white,
A) than for MR spectroscopy with air (black, A) allows
inclusion of larger area of prostate tissue and anterior rectum.
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Fig. 5C —64-year-old man with clinical stage T1c adenocarcinoma of
prostate with Gleason score of 6 and improved spectral resolution of MR
spectroscopy with perfluorocarbon (PFC)-filled endorectal coil. MR spectra
from two hypointense voxels on T2-weighted axial image (A) performed
with air (B) and PFC (C) in endorectal coils show dramatic
improvement in spectral resolution with PFC. Polyamine peaks (Po) are clear in
C but not in B. Line width decreased from 16 to 6 Hz. Larger MR
spectroscopy volume box for MR spectroscopy with PFC (white,
A) than for MR spectroscopy with air (black, A) allows
inclusion of larger area of prostate tissue and anterior rectum.
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Copyright © 2008 by the American Roentgen Ray Society.
