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Measuring Noncalcified Coronary Atherosclerotic Plaque Using Voxel Analysis with MDCT Angiography: Phantom Validation

Adeel Sabir1, Chun-Shan Yam1, Norihiko Yoshimura1, Jacqueline L. Buros2, Alec M. De Grand3, Vassilios Raptopoulos1 and Melvin E. Clouse1

1 Department of Radiology, Beth Israel Deaconess Medical Center/Harvard Medical School, One Deaconess Rd., WCC-302, Boston, MA 02215.
2 PERFUSE Core Laboratory and Data Coordinating Center, Harvard Medical School, Boston, MA.
3 Small Animal Imaging Facility, Harvard Medical School, Boston, MA.


Figure 1
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  		Fig. 1A —Voxel analysis using micro-CT. Cross-sectional micro-CT image of 4.07 mm3 phantom shows line drawn manually by reader. For this particular case, line was drawn across right side of phantom wall. A–B = phantom edges.

 

Figure 2
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  		Fig. 1B —Voxel analysis using micro-CT. Voxel (H) plot of phantom image shows locations of two boundaries (H1, inner wall and lumen; H2, outer wall and epicardial fat) determined by gradient changes. A–B = phantom edges.

 

Figure 3
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  		Fig. 1C —Voxel analysis using micro-CT. Color-coded 3D model of phantom shows three regions at these two boundaries representing arterial wall, lumen, and noncalcified plaque, as in clinical cases.

 

Figure 4
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  		Fig. 1D —Voxel analysis using micro-CT. Three-dimensional model shows final noncalcified plaque volume after removing (peeling off) arterial wall and lumen. Measured volume was 4.05 mm3.

 

Figure 5
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  		Fig. 2A —Voxel analysis using MDCT. Cross-sectional MDCT image of 4.07 mm3 phantom shows line drawn manually by reader. For this particular case, line was drawn across right side of phantom wall. A–B = phantom edges.

 

Figure 6
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  		Fig. 2B —Voxel analysis using MDCT. Voxel (H) plot of phantom image shows locations of two boundaries (H1, inner wall and lumen; H2, outer wall and epicardial fat) determined by gradient changes. A–B = phantom edges.

 

Figure 7
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  		Fig. 2C —Voxel analysis using MDCT. Color-coded 3D model of phantom shows three regions at these two boundaries representing arterial wall, lumen, and noncalcified plaque, as in clinical cases.

 

Figure 8
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  		Fig. 2D —Voxel analysis using MDCT. Three-dimensional model shows final noncalcified plaque volume after removing (peeling off) arterial wall and lumen. Measured volume was 3.71 mm3.

 

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