Evaluation of the Severity of Chronic Hepatitis C with 3-T1H-MR Spectroscopy
Antonio Orlacchio1,
Francesca Bolacchi1,
Marcello Cadioli2,
Alberto Bergamini3,
Valeria Cozzolino1,
Mario Angelico4 and
Giovanni Simonetti1
1 Department of Diagnostic Imaging, Molecular Imaging, Interventional Radiology,
and Radiation Therapy, University Hospital Tor Vergata, Viale Oxford, 81,
00133 Rome, Italy.
2 Philips Healthcare, Monza, Italy.
3 Department of Public Health and Cellular Biology, University Hospital Tor
Vergata, Rome, Italy.
4 Hepatology Unit, Department of Internal Medicine, University Hospital Tor
Vergata, Rome, Italy.
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Fig. 2A —Correlation between water content and disease severity.
Graphs show no statistically significant correlation between water content
(relative units) and degree of steatosis (A), histologic grade
(B), or fibrosis stage (C).
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Fig. 2B —Correlation between water content and disease severity.
Graphs show no statistically significant correlation between water content
(relative units) and degree of steatosis (A), histologic grade
(B), or fibrosis stage (C).
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Fig. 2C —Correlation between water content and disease severity.
Graphs show no statistically significant correlation between water content
(relative units) and degree of steatosis (A), histologic grade
(B), or fibrosis stage (C).
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Fig. 3A —Correlation between lipid level and disease severity. Graphs
show elevation of lipid level (relative units) with severity of steatosis with
clear separation between all steatosis grades (A), between histologic
grade 0–1 versus histologic grade 2–3 hepatitis (B), and
between stage of fibrosis 0–1 versus stage of fibrosis 2–3
hepatitis (C).
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Fig. 3B —Correlation between lipid level and disease severity. Graphs
show elevation of lipid level (relative units) with severity of steatosis with
clear separation between all steatosis grades (A), between histologic
grade 0–1 versus histologic grade 2–3 hepatitis (B), and
between stage of fibrosis 0–1 versus stage of fibrosis 2–3
hepatitis (C).
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Fig. 3C —Correlation between lipid level and disease severity. Graphs
show elevation of lipid level (relative units) with severity of steatosis with
clear separation between all steatosis grades (A), between histologic
grade 0–1 versus histologic grade 2–3 hepatitis (B), and
between stage of fibrosis 0–1 versus stage of fibrosis 2–3
hepatitis (C).
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Fig. 4A —Correlation between metabolite concentration and histologic
grade. Graphs show elevation of concentration (relative units) of
choline-containing compounds (CCC) (A) and glutamine–glutamate
complex (Glx) (B) with increasing grade. Separation between groups is
clear.
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Fig. 4B —Correlation between metabolite concentration and histologic
grade. Graphs show elevation of concentration (relative units) of
choline-containing compounds (CCC) (A) and glutamine–glutamate
complex (Glx) (B) with increasing grade. Separation between groups is
clear.
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Fig. 5A —Correlation between metabolite concentration and degree of
steatosis. Graphs show ratios of concentration (relative units) of
choline-containing compounds (CCC) (A) and glutamine–glutamate
complex (Glx) (B) at various steatosis grades. Clear separation between
steatosis grade 0–1 and grade 2–3 is shown.
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Fig. 5B —Correlation between metabolite concentration and degree of
steatosis. Graphs show ratios of concentration (relative units) of
choline-containing compounds (CCC) (A) and glutamine–glutamate
complex (Glx) (B) at various steatosis grades. Clear separation between
steatosis grade 0–1 and grade 2–3 is shown.
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Fig. 6A —Correlation between metabolite concentration and stage of
fibrosis. Graphs illustrate ratios of concentration (relative units) of
choline-containing compounds (CCC) (A) and glutamine–glutamate
complex (Glx) (B) at various stages of fibrosis. Concentrations of
choline-containing compounds and glutamine–glutamate complex showed no
correlation with severity of fibrosis.
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Fig. 6B —Correlation between metabolite concentration and stage of
fibrosis. Graphs illustrate ratios of concentration (relative units) of
choline-containing compounds (CCC) (A) and glutamine–glutamate
complex (Glx) (B) at various stages of fibrosis. Concentrations of
choline-containing compounds and glutamine–glutamate complex showed no
correlation with severity of fibrosis.
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Fig. 7A —3-T 1H-MR spectra. Spectra of 48-year-old woman
with hepatitis C virus (HCV) with grade 1 hepatitis and mild steatosis
(A), 57-year-old woman with HCV with grade 2 hepatitis and moderate
steatosis (B), and 52-year-old man with HCV with grade 3 hepatitis and
severe steatosis (C) show progressive increase in choline-containing
compound (CCC), glutamine–glutamate complex (Glx), and lipid (Lip)
resonance.
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Fig. 7B —3-T 1H-MR spectra. Spectra of 48-year-old woman
with hepatitis C virus (HCV) with grade 1 hepatitis and mild steatosis
(A), 57-year-old woman with HCV with grade 2 hepatitis and moderate
steatosis (B), and 52-year-old man with HCV with grade 3 hepatitis and
severe steatosis (C) show progressive increase in choline-containing
compound (CCC), glutamine–glutamate complex (Glx), and lipid (Lip)
resonance.
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Fig. 7C —3-T 1H-MR spectra. Spectra of 48-year-old woman
with hepatitis C virus (HCV) with grade 1 hepatitis and mild steatosis
(A), 57-year-old woman with HCV with grade 2 hepatitis and moderate
steatosis (B), and 52-year-old man with HCV with grade 3 hepatitis and
severe steatosis (C) show progressive increase in choline-containing
compound (CCC), glutamine–glutamate complex (Glx), and lipid (Lip)
resonance.
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Fig. 8A —Scatterplots show distribution of complete set of cases by
use of two first discriminant functions obtained for linear discriminant
analysis: y-axis, value obtained with first discriminant function;
x-axis, value obtained with second discriminant function. Plot shows
complete set of cases for grading evaluation. Discriminant function 1 (score
1) has most discriminating power according to its eigenvalue of 9, 32
(F = 18.5; p < 0.001; Wilks  = 0.096).
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Fig. 8B —Scatterplots show distribution of complete set of cases by
use of two first discriminant functions obtained for linear discriminant
analysis: y-axis, value obtained with first discriminant function;
x-axis, value obtained with second discriminant function. Plot shows
complete set of cases for steatosis evaluation. Discriminant function 1 (score
1) has most discriminating power (eigenvalue, 9, 26; F = 20.2;
p < 0.001; Wilks = 0.085).
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Copyright © 2008 by the American Roentgen Ray Society.
