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Multicenter Randomized Controlled Trial of the Costs and Effects of Noninvasive Diagnostic Imaging in Patients with Peripheral Arterial Disease: The DIPAD Trial

Rody Ouwendijk1,2, Marianne de Vries3, Theo Stijnen2, Peter M. T. Pattynama1, Marc R. H. M. van Sambeek4, Jaap Buth5, Alexander V. Tielbeek6, Daan A. van der Vliet7, Leo J. SchutzeKool8, Peter J. E. H. M. Kitslaar9, Michiel W. de Haan3, Jos M. A. van Engelshoven3, M. G. Myriam Hunink1,2,10 for the Program for the Assessment of Radiological Technology

1 Department of Radiology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands.
2 Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands.
3 Department of Radiology, Maastricht University Hospital and Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands.
4 Department of Vascular Surgery, Erasmus MC, Rotterdam, The Netherlands.
5 Department of Vascular Surgery, St. Catharina Hospital, Eindhoven, The Netherlands.
6 Department of Radiology, St. Catharina Hospital, Eindhoven, The Netherlands.
7 Department of Vascular Surgery, University Medical Centre, Nijmegen, The Netherlands.
8 Department of Radiology, University Medical Centre, Nijmegen, The Netherlands.
9 Department of Vascular Surgery, Maastricht University Hospital and Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands.
10 Department of Health Policy and Management, Harvard School of Public Health, Boston, MA.


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  		Fig. 1 —Flow diagram illustrates reasons for exclusion, random assignment of patients to diagnostic test groups, diagnostic tests that patients actually underwent, schematic representation of follow-up, and actual number of patients included in analysis. Patients meeting all eligibility criteria were randomly assigned to undergo MR angiography (MRA) or currently used test, which was duplex sonography (DS) in three hospitals and CT angiography (CTA) in one hospital as initial imaging test. DSA = digital subtraction angiography. aSome patients underwent several interventional procedures. bThese patients did not undergo any diagnostic or therapeutic intervention and no data are available.

 

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