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Potential Role of Diffusion Tensor MRI in the Differential Diagnosis of Mild Cognitive Impairment and Alzheimer's Disease

¹ Clinica de Diagnóstico Por Imagem, Ave. das Américas 4666, sala 32522649-900, Rio de Janeiro, Brazil.
² Multi-Imagem, Rio de Janeiro, Brazil.
³ Department of Radiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

View larger version (130K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1A —68-year-old woman with mild cognitive impairment. Position of regions of interest. Fractional anisotropy color-coded map shows splenium of corpus callosum (1), right posterior cingulate gyrus (2), and left posterior cingulate gyrus (3).

View larger version (115K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1B —68-year-old woman with mild cognitive impairment. Position of regions of interest. Fractional anisotropy color-coded map shows right superior longitudinal fascicle (1) and left superior longitudinal fascicle (2).

View larger version (138K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1C —68-year-old woman with mild cognitive impairment. Position of regions of interest. Fractional anisotropy color-coded map shows right hippocampus (1) and left hippocampus (2).

View larger version (13K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2A —Fractional anisotropy values of controls, patients with possible Alzheimer's disease, patients with probable Alzheimer's disease, and patients with mild cognitive impairment. Graphs show fractional anisotropy in right (A) and left (B) superior longitudinal fascicles, right (C) and left (D) cingulate gyri, right (E) and left (F) hippocampi, and splenium of corpus callosum (G).

View larger version (13K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2B —Fractional anisotropy values of controls, patients with possible Alzheimer's disease, patients with probable Alzheimer's disease, and patients with mild cognitive impairment. Graphs show fractional anisotropy in right (A) and left (B) superior longitudinal fascicles, right (C) and left (D) cingulate gyri, right (E) and left (F) hippocampi, and splenium of corpus callosum (G).

View larger version (13K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2C —Fractional anisotropy values of controls, patients with possible Alzheimer's disease, patients with probable Alzheimer's disease, and patients with mild cognitive impairment. Graphs show fractional anisotropy in right (A) and left (B) superior longitudinal fascicles, right (C) and left (D) cingulate gyri, right (E) and left (F) hippocampi, and splenium of corpus callosum (G).

View larger version (12K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2D —Fractional anisotropy values of controls, patients with possible Alzheimer's disease, patients with probable Alzheimer's disease, and patients with mild cognitive impairment. Graphs show fractional anisotropy in right (A) and left (B) superior longitudinal fascicles, right (C) and left (D) cingulate gyri, right (E) and left (F) hippocampi, and splenium of corpus callosum (G).

View larger version (12K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2E —Fractional anisotropy values of controls, patients with possible Alzheimer's disease, patients with probable Alzheimer's disease, and patients with mild cognitive impairment. Graphs show fractional anisotropy in right (A) and left (B) superior longitudinal fascicles, right (C) and left (D) cingulate gyri, right (E) and left (F) hippocampi, and splenium of corpus callosum (G).

View larger version (11K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2F —Fractional anisotropy values of controls, patients with possible Alzheimer's disease, patients with probable Alzheimer's disease, and patients with mild cognitive impairment. Graphs show fractional anisotropy in right (A) and left (B) superior longitudinal fascicles, right (C) and left (D) cingulate gyri, right (E) and left (F) hippocampi, and splenium of corpus callosum (G).

View larger version (12K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2G —Fractional anisotropy values of controls, patients with possible Alzheimer's disease, patients with probable Alzheimer's disease, and patients with mild cognitive impairment. Graphs show fractional anisotropy in right (A) and left (B) superior longitudinal fascicles, right (C) and left (D) cingulate gyri, right (E) and left (F) hippocampi, and splenium of corpus callosum (G).

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