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Method for Decreasing Uptake of 18F-FDG by Hypermetabolic Brown Adipose Tissue on PET

Gethin Williams1 and Gerald M. Kolodny

1 Both authors: Department of Radiology, Division of Nuclear Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215.


Figure 1
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  		Fig. 1A —PET/CT scans show scores of uptake of 18F-FDG by brown adipose tissue. In grading system, score of 0 represented no uptake; 6, very intense uptake. Numbers on images indicate scores. 40-year-old woman with history of large cell lymphoma to thyroid gland; score is 1.

 

Figure 2
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  		Fig. 1B —PET/CT scans show scores of uptake of 18F-FDG by brown adipose tissue. In grading system, score of 0 represented no uptake; 6, very intense uptake. Numbers on images indicate scores. 41-year-old woman with non-Hodgkin's lymphoma who was seen for restaging; score is 3.

 

Figure 3
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  		Fig. 1C —PET/CT scans show scores of uptake of 18F-FDG by brown adipose tissue. In grading system, score of 0 represented no uptake; 6, very intense uptake. Numbers on images indicate scores. 76-year-old woman undergoing staging for lymphoma; score is 4.

 

Figure 4
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  		Fig. 1D —PET/CT scans show scores of uptake of 18F-FDG by brown adipose tissue. In grading system, score of 0 represented no uptake; 6, very intense uptake. Numbers on images indicate scores. 53-year-old woman with history of breast cancer who presented with right lung nodule; score is 6.

 

Figure 5
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  		Fig. 2A —34-year-old woman who underwent restaging of lymphoma. PET scan shows areas of brown adipose tissue.

 

Figure 6
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  		Fig. 2B —34-year-old woman who underwent restaging of lymphoma. CT scan confirms areas of brown adipose tissue by fat density and location.

 

Figure 7
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  		Fig. 2C —34-year-old woman who underwent restaging of lymphoma. Fused PET/CT scan shows 18F-FDG uptake corresponding to fat density in B.

 

Figure 8
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  		Fig. 3A —39-year-old woman with Hodgkin's disease who presented for restaging. Serial 18F-FDG PET/CT scans for which patient prepared by fasting in February 2004 (A) and December 2004 (B) and with high-fat, very-low-carbohydrate, protein-permitted diet in November 2005 (C) show suppression of FDG uptake by hypermetabolic brown adipose tissue.

 

Figure 9
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  		Fig. 3B —39-year-old woman with Hodgkin's disease who presented for restaging. Serial 18F-FDG PET/CT scans for which patient prepared by fasting in February 2004 (A) and December 2004 (B) and with high-fat, very-low-carbohydrate, protein-permitted diet in November 2005 (C) show suppression of FDG uptake by hypermetabolic brown adipose tissue.

 

Figure 10
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  		Fig. 3C —39-year-old woman with Hodgkin's disease who presented for restaging. Serial 18F-FDG PET/CT scans for which patient prepared by fasting in February 2004 (A) and December 2004 (B) and with high-fat, very-low-carbohydrate, protein-permitted diet in November 2005 (C) show suppression of FDG uptake by hypermetabolic brown adipose tissue.

 

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