AJR
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Venkatesh, S. K.
Right arrow Articles by Ehman, R. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Venkatesh, S. K.
Right arrow Articles by Ehman, R. L.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Hotlight (NEW!)
Right arrow
What's Hotlight?

MR Elastography of Liver Tumors: Preliminary Results

Sudhakar K. Venkatesh1,2, Meng Yin1, James F. Glockner1, Naoki Takahashi1, Philip A. Araoz1, Jayant A. Talwalkar3 and Richard L. Ehman1

1 Department of Radiology, Mayo Clinic and Foundation, 200 First St. SW, Opus Bldg., Rochester, MN 55905.
2 Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
3 Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.


Figure 1
View larger version (59K):
[in this window]
[in a new window]
[as a PowerPoint slide]
  		Fig. 1 —77-year-old man with cholangiocarcinoma.

A, Gadolinium-enhanced T1-weighted MR image shows enhanced tumor (arrow) involving left hepatic duct and invading surrounding left lobe of liver.

B, Elastogram shows mean stiffness of tumor (arrow) is 15.5 kPa and that of liver parenchyma is 4.3 kPa.

 

Figure 2
View larger version (94K):
[in this window]
[in a new window]
[as a PowerPoint slide]
  		Fig. 2 —78-year-old man with cryptogenic cirrhosis and biopsy-proven hepatocellular carcinoma.

A and B, Dynamic gadolinium-enhanced T1-weighted MR images show enhanced tumor (arrow) in right lobe of liver during arterial phase (A) with washout during portal venous phase (B). Arrowhead = fat-containing region within tumor.

C and D, Dynamic gadolinium-enhanced T1-weighted MR images show enhanced tumor (arrow) in right lobe of liver during arterial phase (A) with washout during portal venous phase (B). Arrowhead = fat-containing region within tumor.

 

Figure 3
View larger version (51K):
[in this window]
[in a new window]
[as a PowerPoint slide]
  		Fig. 3 —55-year-old woman with metastatic colon cancer in right lobe of liver and diffuse fatty liver.

A, T2-weighted image shows single hyperintense lesion (arrow) in periphery of right lobe of liver.

B, Wave image shows prolongation of shear wave through tumor (arrow) compared with surrounding normal liver parenchyma.

C, Elastogram shows tumor (arrow) as hot spot with stiffness value of 6.2 kPa, suggestive of malignant tumor. Finding was confirmed at surgery to be metastasis from colon cancer.

 

Figure 4
View larger version (70K):
[in this window]
[in a new window]
[as a PowerPoint slide]
  		Fig. 4 —39-year-old man with hepatic adenoma.

A, T2-weighted MR image (A) shows hyperintense 8-cm adenoma (arrow) in right lobe of liver.

B, Gadolinium-enhanced 3D spoiled gradient-recalled echo MR image shows intense arterial phase enhancement (arrow). Washout was evident in portal venous phase (not shown).

C, Axial MR elastographic wave image shows good illumination of tumor (circle). Waves in tumor have slightly longer wavelength than those in surrounding normal liver parenchyma.

D, Elastogram with region of interest corresponding to tumor shows shear stiffness value of tumor is 3.1 kPa and of surrounding liver is 2.4 kPa.

 

Figure 5
View larger version (45K):
[in this window]
[in a new window]
[as a PowerPoint slide]
  		Fig. 5 —51-year-old woman with hemangioma in liver.

A and B, T1-weighted images during arterial (A) and delayed (B) phases show enhancement pattern typical of hemangioma (arrow).

C, Stiffness map shows stiffness of hemangioma (circle) is 3.2 kPa, whereas that of surrounding liver parenchyma is 2.3 kPa.

 

Figure 6
View larger version (10K):
[in this window]
[in a new window]
[as a PowerPoint slide]
  		Fig. 6 —Graph shows box plots of shear stiffness of tissues. Cutoff value of 5 kPa separates malignant tumors from benign tumors and normal liver. Stiffness values of fibrotic liver overlap those of benign and malignant tumors.

 

Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?



HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2008 by the American Roentgen Ray Society.