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How Accurately Does Current Fetal Imaging Identify Posterior Fossa Anomalies?

Catherine Limperopoulos1,2,3, Richard L. Robertson, Jr.4, Omar S. Khwaja1, Caroline D. Robson4, Judy A. Estroff4, Carole Barnewolt4, Deborah Levine5, Donna Morash6, Luanne Nemes6, Linda Zaccagnini6 and Adré J. du Plessis1

1 Fetal-Neonatal Neurology Research Program, Department of Neurology, Children's Hospital Boston and Harvard Medical School, Boston, MA.
2 Present address: Division of Pediatric Neurology, Montreal Children's Hospital, 2300 Tupper St., A-334, Montreal, QC H3H 1P3, Canada.
3 Present address: Department of Neurology and Neurosurgery, School of Physical and Occupational Therapy and Department of Pediatrics, McGill University, Montreal, QC, Canada.
4 Department of Radiology, Children's Hospital Boston and Harvard Medical School, Boston, MA.
5 Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.
6 Advanced Fetal Care Center, Children's Hospital Boston and Harvard Medical School, Boston, MA.


Figure 1
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  		Fig. 1 —Summary of outcomes for all posterior fossa anomalies identified over 5-year study period.

 

Figure 2
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  		Fig. 2A —Postnatal MRI confirms fetal MRI findings and shows additional findings not apparent on fetal MRI. Single-shot fast spin-echo T2-weighted images of fetus at 21 weeks' gestation show hypoplasia of vermis and corpus callosum (A) and right cerebellar hemisphere (B).

 

Figure 3
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  		Fig. 2B —Postnatal MRI confirms fetal MRI findings and shows additional findings not apparent on fetal MRI. Single-shot fast spin-echo T2-weighted images of fetus at 21 weeks' gestation show hypoplasia of vermis and corpus callosum (A) and right cerebellar hemisphere (B).

 

Figure 4
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  		Fig. 2C —Postnatal MRI confirms fetal MRI findings and shows additional findings not apparent on fetal MRI. Coronal T2-weighted image of 2-day-old female neonate confirms findings shown on A and B; however, in addition, postnatal MRI study shows thickened dysmorphic cerebellar cortex and right occipital subependymal nodular heterotopia not apparent on fetal MRI.

 

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