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Chemoembolization of Hepatic Metastases from Ocular Melanoma: Assessment of Response with Contrast-Enhanced and Diffusion-Weighted MRI

¹ All authors: Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Hospital, 601 N Caroline St., Rm. 3235A, Baltimore, MD 21287.

View larger version (103K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1A —60-year-old woman with hepatic metastases from ocular melanoma. Changes in enhancement and apparent diffusion coefficient after transarterial chemoembolization. Gadolinium-enhanced arterial phase MR image (TR/TE, 5.1/1.2) shows 3.1-cm mass (arrow) in left lobe with almost complete (100%) enhancement.

View larger version (65K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1B —60-year-old woman with hepatic metastases from ocular melanoma. Changes in enhancement and apparent diffusion coefficient after transarterial chemoembolization. Diffusion-weighted MR image (6,500/110) shows hyperintense mass (arrow).

View larger version (82K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1C —60-year-old woman with hepatic metastases from ocular melanoma. Changes in enhancement and apparent diffusion coefficient after transarterial chemoembolization. After placement of region of interest on entire mass (arrow), apparent diffusion coefficient is 0.00138 mm2/s.

View larger version (98K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1D —60-year-old woman with hepatic metastases from ocular melanoma. Changes in enhancement and apparent diffusion coefficient after transarterial chemoembolization. Unenhanced CT scan of abdomen shows intense deposition of iodized oil in mass (arrow) after transarterial chemoembolization.

View larger version (94K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1E —60-year-old woman with hepatic metastases from ocular melanoma. Changes in enhancement and apparent diffusion coefficient after transarterial chemoembolization. Gadolinium-enhanced arterial phase MR image (TR/TE, 5.1/1.2) after transarterial chemoembolization shows significant decrease in enhancement of mass (arrow), now less than 10%. Size of mass decreased slightly to 2.9 cm.

View larger version (81K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1F —60-year-old woman with hepatic metastases from ocular melanoma. Changes in enhancement and apparent diffusion coefficient after transarterial chemoembolization. Diffusion-weighted MR image (6,500/110) after transarterial chemoembolization.

View larger version (86K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 1G —60-year-old woman with hepatic metastases from ocular melanoma. Changes in enhancement and apparent diffusion coefficient after transarterial chemoembolization. After placement of region of interest on entire mass (arrow), apparent diffusion coefficient is 0.00229 mm2/s, confirming increasing cellular necrosis.

View larger version (9K): [in this window] [in a new window] [as a PowerPoint slide]   Fig. 2 —Graph shows changes in apparent diffusion coefficient after treatment. ADC = apparent diffusion coefficient.

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