Frequency of Serum Creatinine Changes in the Absence of Iodinated Contrast Material: Implications for Studies of Contrast Nephrotoxicity
Jeffrey H. Newhouse1,
David Kho1,2,
Qasim A. Rao1,3 and
Justin Starren1,4,5
1 Department of Radiology, Columbia University Medical Center, 630 W 168th St.,
New York, NY 10032.
2 Present address: Department of Radiology, Winthrop University Hospital,
Mineola, NY.
3 Present address: Department of Radiology, Bridgeport Hospital, Bridgeport,
CT.
4 Department of Medical Informatics, Columbia University Medical Center, New
York, NY.
5 Present address: Biomedical Informatics Research Center, Marshfield Clinic
Research Foundation, Marshfield, WI.
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Fig. 1 —Fraction of patients with threshold creatinine change. Figure
shows fraction of patients having relative change in creatinine level at
indicated percentage on a specific day versus day 0. Lower thresholds are more
likely to be reached, and decreases are more common than increases. Totals sum
to greater than 100% because higher percentage of change (e.g., 50%) is
included in results for lower thresholds (e.g., 25%).
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Fig. 2 —Cumulative fraction of patients with fractional threshold
creatinine change. Figure shows fraction of patients having a threshold change
on any day up to indicated day versus day 0. Lower thresholds are more likely
to be reached, and decreases are more common than increases. Totals sum to
greater than 100% because higher percentage of change (e.g., 50%) is included
in results for lower thresholds (e.g., 25%).
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Fig. 3 —Cumulative fraction of patients with absolute threshold
creatinine change. Figure shows fraction of patients having a change of at
least value indicated on any of the days up to indicated day versus day 0.
Lower thresholds are more likely to be reached, and decreases are more common
than increases. Totals sum to greater than 100% because higher thresholds
(e.g., 1.0) are included in totals with lower thresholds.
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Fig. 4A —Comparison of reported contrast-induced creatinine increase
and observed frequencies. Frequencies observed in this study (percentage of
increase [A] and absolute increase [B]) in our
non-contrast-exposed population are indicated by solid circles. Open circles
represent previously published data (also summarized in
Table 2). Number adjacent to
each open circle is number of corresponding publication in reference list.
Overall risk of nephropathy in patients receiving contrast material is not
clearly different from risk in patients who have not received it.
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Fig. 4B —Comparison of reported contrast-induced creatinine increase
and observed frequencies. Frequencies observed in this study (percentage of
increase [A] and absolute increase [B]) in our
non-contrast-exposed population are indicated by solid circles. Open circles
represent previously published data (also summarized in
Table 2). Number adjacent to
each open circle is number of corresponding publication in reference list.
Overall risk of nephropathy in patients receiving contrast material is not
clearly different from risk in patients who have not received it.
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Copyright © 2008 by the American Roentgen Ray Society.
