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In Vivo Trabecular Bone Morphologic and Mechanical Relationship Using High-Resolution 3-T MRI

Angel Alberich-Bayarri1, Luis Marti-Bonmati1, Roberto Sanz-Requena1, Elena Belloch1 and David Moratal2

1 Department of Radiology, Hospital Quirón, Avda. Blasco Ibáñez, 14, 46010 Valencia, Spain.
2 Electronics Engineering Department, Universidad Politècnica de València, Valencia, Spain.


Figure 1
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Fig. 1 Example of axial MR image acquired for trabecular bone characterization in 24-year-old healthy man. Acquired isotropic spatial resolution of 180 µm x 180 µm x 180 µm is achieved.

 

Figure 2
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Fig. 2 Rendered 3D reconstruction of small portion of the trabecular bone in 31-year-old healthy man provides better observation of details.

 

Figure 3
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Fig. 3 Finite element mesh of large-volume trabecular bone reconstruction in 36-year-old healthy woman based on hexahedron or brick elements. Zoomed region shows detail of brick elements piled up and compounding structure.

 

Figure 4
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Fig. 4 On chart, different behaviors of correlation of apparent elastic modulus with square of bone volume-to-total volume ratio fraction parameter can be observed depending on analyzed volume of interest (VOI). Small VOI samples present no relationship of dependence with square of bone volume-to-total volume ratio fraction parameter. Large VOI samples have linear behavior and high correlation between apparent elastic modulus and square of bone volume-to-total volume ratio. {square} = large VOI, {triangleup} = small VOI.

 

Figure 5
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Fig. 5 Bland-Altman plot shows results of apparent elastic modulus for small volume (EappS) and large volume (EappL) analyzed.

 

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