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Biliary Intraductal Papillary-Mucinous Neoplasm Manifesting Only as Dilatation of the Hepatic Lobar or Segmental Bile Ducts: Imaging Features in Six Patients

Jae Hoon Lim1, Kee-Taek Jang2 and Dongil Choi1

1 Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, Seoul, Korea.
2 Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.


Figure 1
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Fig. 1A 73-year-old man with intraductal papillary-mucinous adenoma spreading along entire length of intrahepatic bile ducts of left hepatic lobe. Unenhanced CT images show severe dilatation of bile ducts of left hepatic lobe containing several small calcified stones (arrows).

 

Figure 2
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Fig. 1B 73-year-old man with intraductal papillary-mucinous adenoma spreading along entire length of intrahepatic bile ducts of left hepatic lobe. Unenhanced CT images show severe dilatation of bile ducts of left hepatic lobe containing several small calcified stones (arrows).

 

Figure 3
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Fig. 1C 73-year-old man with intraductal papillary-mucinous adenoma spreading along entire length of intrahepatic bile ducts of left hepatic lobe. Contrast-enhanced CT images show severe dilatation of bile ducts of left hepatic lobe with no visible hepatic parenchyma because of severe parenchymal atrophy. Dilated intrahepatic ducts are filled with fluid and small stones (arrows).

 

Figure 4
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Fig. 1D 73-year-old man with intraductal papillary-mucinous adenoma spreading along entire length of intrahepatic bile ducts of left hepatic lobe. Contrast-enhanced CT images show severe dilatation of bile ducts of left hepatic lobe with no visible hepatic parenchyma because of severe parenchymal atrophy. Dilated intrahepatic ducts are filled with fluid and small stones (arrows).

 

Figure 5
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Fig. 1E 73-year-old man with intraductal papillary-mucinous adenoma spreading along entire length of intrahepatic bile ducts of left hepatic lobe. Endoscopic retrograde cholangiogram shows marked dilatation of intrahepatic and extrahepatic ducts. Large and small filling defects (arrows) due to stones and mucin are evident.

 

Figure 6
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Fig. 1F 73-year-old man with intraductal papillary-mucinous adenoma spreading along entire length of intrahepatic bile ducts of left hepatic lobe. Photograph of resected specimen of left hepatic lobe shows severe dilatation of bile ducts with fibrous thickening (arrows). Hepatic parenchyma is almost absent. No tumor is visible in dilated bile ducts. Bile ducts were filled with mucopurulent fluid.

 

Figure 7
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Fig. 1G 73-year-old man with intraductal papillary-mucinous adenoma spreading along entire length of intrahepatic bile ducts of left hepatic lobe. Photomicrograph shows intraductal proliferation of papillary-mucinous epithelium of adenoma. (H and E, x40)

 

Figure 8
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Fig. 2A 66-year-old woman with epithelial hyperplasia and moderate to severe dysplasia of entirety of right hepatic bile ducts. Contrast-enhanced CT images show markedly dilated bile ducts in right and left hepatic lobes and extrahepatic ducts (arrow, C). Severe parenchymal atrophy of right hepatic lobe is evident. GB = gallbladder.

 

Figure 9
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Fig. 2B 66-year-old woman with epithelial hyperplasia and moderate to severe dysplasia of entirety of right hepatic bile ducts. Contrast-enhanced CT images show markedly dilated bile ducts in right and left hepatic lobes and extrahepatic ducts (arrow, C). Severe parenchymal atrophy of right hepatic lobe is evident. GB = gallbladder.

 

Figure 10
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Fig. 2C 66-year-old woman with epithelial hyperplasia and moderate to severe dysplasia of entirety of right hepatic bile ducts. Contrast-enhanced CT images show markedly dilated bile ducts in right and left hepatic lobes and extrahepatic ducts (arrow, C). Severe parenchymal atrophy of right hepatic lobe is evident. GB = gallbladder.

 

Figure 11
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Fig. 2D 66-year-old woman with epithelial hyperplasia and moderate to severe dysplasia of entirety of right hepatic bile ducts. Cholangiogram through drainage catheter shows severe dilatation of extrahepatic duct containing multiple elongated filling defects (arrows) caused by mucin.

 

Figure 12
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Fig. 2E 66-year-old woman with epithelial hyperplasia and moderate to severe dysplasia of entirety of right hepatic bile ducts. Photomicrograph of pathologic specimen shows intraductal proliferation of papillary-mucinous epithelium of high-grade dysplasia and dysplastic cells diffusely lining bile ducts. (H and E, x40)

 

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