Accuracy of High-Resolution CT in the Diagnosis of Diffuse Lung Disease: Effect of Predominance and Distribution of Findings
Baskaran Sundaram1,
Barry H. Gross1,
Fernando J. Martinez2,
Eugene Oh1,3,
Nestor L. Müller4,
Matt Schipper1,5 and
Ella A. Kazerooni1
1 Department of Radiology, University of Michigan Health System, Cardiovascular
Center, Rm. 5481, 1500 E Medical Center Dr., Ann Arbor, MI 48109-5868.
2 Department of Internal Medicine, University of Michigan Health System, Ann
Arbor, MI.
3 Present address: Valley Radiologists/SDI, Ltd., Glendale, AZ.
4 Department of Radiology, Vancouver General Hospital, University of British
Columbia, Vancouver, BC, Canada.
5 Present address: Innovative Analytics, Kalamazoo, MI.

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Fig. 1 —61-year-old woman with predominant CT finding of honeycombing
(arrow), which is highly specific for usual interstitial pneumonitis.
Findings at surgical lung biopsy were consistent with usual interstitial
pneumonitis.
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Fig. 2 — 60-year-old woman with predominant CT finding of bilateral
multiple thin-walled lung cysts (white arrow) uniformly distributed
from lung apex to base. Incidental small left pneumothorax (black
arrow) is evident. Left renal and left adrenal gland masses were found
and surgically removed. Both masses were histologically proven angiomyolipoma.
Lung changes were presumed to be due to lymphangiomyomatosis.
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Fig. 3 —51-year-old man with CT finding of nodular
peribronchovascular interstitial thickening (arrow). Results of
transbronchial biopsy were positive for multiple epithelioid granuloma in
alveolar parenchyma and bronchial wall, suggesting sarcoidosis. Results of
special stains for acid-fast bacilli and fungi were negative.
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Fig. 4 —56-year-old woman with predominant CT finding of ground-glass
opacification. Centrilobular ground-glass opacities are diffusely distributed
in craniocaudal direction with no other predominant findings recorded.
Histologic diagnosis was hypersensitivity pneumonitis.
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Copyright © 2008 by the American Roentgen Ray Society.