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Radiologic–Pathologic Conferences of the University of Rochester School of Medicine: Inflammatory Pseudotumor of the Spleen

Shweta Bhatt1, Rochelle Simon2 and Vikram S. Dogra1

1 Department of Imaging Sciences, University of Rochester School of Medicine, 601 Elmwood Ave., Box 648, Rochester, NY 14642.
2 Department of Pathology, University of Rochester School of Medicine, Rochester, NY.


Figure 1
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  		Fig. 1A —31-year-old man with inflammatory pseudotumor of spleen. Contrast-enhanced axial CT scan in portal venous phase shows well-circumscribed splenic lesion measuring 5.3 x 3.8 x 4.8 cm with central calcification and peripheral uniform enhancement.

 

Figure 2
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  		Fig. 1B —31-year-old man with inflammatory pseudotumor of spleen. Lesion shows complete filling with contrast materialon delayed CT image.

 

Figure 3
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  		Fig. 1C —31-year-old man with inflammatory pseudotumor of spleen. Fast multiplanar spoiled gradient-echo T1-weighted image (TR/TE, 215/1.6) in axial plane shows well-circumscribed splenic lesion that is almost isointense to splenic parenchyma.

 

Figure 4
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  		Fig. 1D —31-year-old man with inflammatory pseudotumor of spleen. Lesion has low signal intensity on T2-weighted single shot fast spin-echo sequence (94,285/463).

 

Figure 5
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  		Fig. 1E —31-year-old man with inflammatory pseudotumor of spleen. After splenectomy, cut surface of corresponding gross specimen shows well-circumscribed inflammatory pseudotumor in spleen.

 

Figure 6
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  		Fig. 1F —31-year-old man with inflammatory pseudotumor of spleen. Low-magnification photomicrograph of normal spleen shows red (R) and white (W) pulp on left adjacent to inflammatory pseudotumor (T) on right. (H and E, x100)

 

Figure 7
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  		Fig. 1G —31-year-old man with inflammatory pseudotumor of spleen. Higher-magnification photomicrograph shows spindle cells (arrows) and large, spindled and ovoid, angulated vesicular nuclei. Note background of sclerosis with heavy mixed inflammatory infiltrate of lymphocytes and small round dark nuclei, plasma cells (arrowheads), and occasional eosinophils. (H and E, x400)

 

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