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Differences in Sonographic Conspicuity According to Papillary Thyroid Cancer Subtype: Results of the Ukrainian–American Cohort Study After the Chornobyl Accident

Patrick O'Kane1, Evgeniy Shelkovoy2, Robert J. McConnell3, Victor Shpak2, Laurence Parker1, Tatiana I. Bogdanova2, Alina Brenner4, Yuri Naida2, Andrea Frangos1, Lydia Zablotska5, Jacob Robbins6,7, Ellen Greenebaum8, Lydia Y. Zurnadzhy2, Mykolo Tronko2 and Maureen Hatch9

1 Department of Radiology, Thomas Jefferson University Hospital, 10th St. and Walnut St., 796 Main Bldg., Philadelphia, PA 19107.
2 Institute of Endocrinology and Metabolism, Kyiv, Ukraine.
3 Department of Medicine, The Thyroid Clinic, College of Physicians and Surgeons, Columbia University, New York, NY.
4 Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
5 Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.
6 Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
7 Deceased.
8 Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY.
9 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.


Figure 1
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Fig. 1A Photomicrographs show histologic subtypes of papillary carcinoma. Papillary variant.

 

Figure 2
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Fig. 1B Photomicrographs show histologic subtypes of papillary carcinoma. Follicular variant.

 

Figure 3
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Fig. 1C Photomicrographs show histologic subtypes of papillary carcinoma. Solid variant.

 

Figure 4
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Fig. 1D Photomicrographs show histologic subtypes of papillary carcinoma. Mixed papillary–follicular variant.

 

Figure 5
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Fig. 2A Reference examples for grading sonographic conspicuity of thyroid nodules. Sonogram shows grade 1 nodule (cursors): almost invisible, could easily be missed.

 

Figure 6
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Fig. 2B Reference examples for grading sonographic conspicuity of thyroid nodules. Sonogram shows grade 2 nodule: subtle, could be missed in some cases.

 

Figure 7
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Fig. 2C Reference examples for grading sonographic conspicuity of thyroid nodules. Sonogram shows grade 3 nodule: fairly visible, should be seen in most cases.

 

Figure 8
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Fig. 2D Reference examples for grading sonographic conspicuity of thyroid nodules. Sonogram shows grade 4 nodule: clearly visible, should rarely be missed.

 

Figure 9
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Fig. 2E Reference examples for grading sonographic conspicuity of thyroid nodules. Sonogram shows grade 5 nodule (cursors): completely obvious, should never be missed.

 

Figure 10
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Fig. 3 Graph shows mean conspicuity scores for papillary carcinoma subtypes by reader. Mean score for each subtype differed by reader, but there was fair agreement among readers on relative conspicuity of each subtype.

 

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