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Fig. 2D. —Rabbit thigh with VX2 carcinoma (6-7 days after tumor inoculation). Photomicrograph shows necrotic debris (solid arrow) surrounded by thick fibrous capsule (arrowheads). Viable tumor tissue is present only in right posterior aspect of lesion (open arrow), corresponding with nodular thickening of enhanced rim on MR images (arrow, B). Peripheral enhanced rim on MR images represents thick fibrous capsule without viable tumor cells. Central mildly enhanced area with gadolinium mesoporphyrin (arrow, C) represents necrotic area with tissue debris. (H and E, x5)

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