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Fig. 1. —35-year-old woman with multiple sclerosis. Axial T1-weighted MR image shows left parietal focal lesions in periventricular white matter that were categorized as hypointense (solid arrow) because signal intensity is visibly lower than that of normal gray matter. Note other lesions that were categorized as isointense (open arrow) because signal intensity was isointense to that of normal gray matter.

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