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Fig. 10. —52-year-old man with hypersensitivity reaction; patient was receiving methotrexate for rheumatoid arthritis. High-resolution CT scan shows poorly defined centrilobular nodules (arrows) and extensive areas of ground-glass attenuation. Differential diagnosis includes interstitial pneumonitis related to rheumatoid arthritis, opportunistic infection, and adverse drug reaction. Diagnosis was confirmed at open lung biopsy.





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