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Fig. 4. —Graph shows theoretic signal change as function of T1/T2 for fast imaging with steady-state precession (true FISP), plotted for three excitation flip angles using formula in literature [11, 13]. Scale on x-axis corresponds to myelination process that causes increase of T1/T2 from 2500/400 msec (approximately 6.3%) to 900/80 msec (approximately 11.3%). For 70° flip angle (solid line) used in this study, myelinated white matter has signal intensity of 50% less than that in nonmyelinated white matter in true FISP images. This decreasing change provides conspicuous contrast in true FISP images, revealing myelination as low-signal-intensity areas. Dotted line=30° flip angle, dashed line=50° flip angle.

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