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Fig. 1. —Computer-generated T2-weighted (left image) and fluid-attenuated inversion recovery (FLAIR) maps (center image, 40 msec; right image 140 msec) show 12 simulated lesions placed in white matter of cerebral hemisphere parallel to lateral ventricle. T1 relaxation time of lesions varied from 800 msec (posteriormost lesion) to 3000 msec (anteriormost lesion) by increments of 200 msec. All simulated lesions were hyperintense to white matter on T2-weighted maps. On FLAIR maps, simulated lesions changed from hyperintense to hypointense with increasing T1 relaxation time. Lesions with identical T1 relaxation times were hypointense on short-TE FLAIR and hyperintense on long-TE FLAIR (arrowheads). Also, lesions that were hyperintense on T2-weighted sequences were invisible on FLAIR sequences (circles).

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