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Fig. 2. —Drawing shows cardiac defects, abnormal facies, thymic hypoplasia, cleft palate, and hypocalcemia from deletions in chromosome 22 (CATCH-22). 22q11 locus (A), DiGeorge-critical segment, is located on long arm of chromosome 22. Neural crest migration (B) is shown by stippled arrows, which depict migrational routes of neural crest cells to various primordia affected in CATCH-22. Clinical manifestations of CATCH-22 (C), including facial dysmorphism, hypocalcemia, immunodeficiency resulting from absence of parathyroid and thymic development, and congenital heart and aortic arch diseases, are illustrated.

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