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Fig. 5. —Drawing shows pathophysiologic schema for development of different types of gastric carcinoid tumors. Type I carcinoid tumors are small benign tumors, arising in setting of chronic atrophic gastritis and chronic hypergastrinemia. Type II tumors can be large and polypoid; arise in patients with multiple endocrine neoplasia-type I and Zollinger-Ellison syndrome; and are prone to nodal metastasis. Type III tumors, which are not associated with hypergastrinemic state, are large, sporadic, solitary tumors prone to nodal and hepatic metastases, as well as to carcinoid syndrome.

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