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Fig. 1D. —Functional MR images (group composite) of regional brain activation during cold task. Red—yellow areas represent brain regions that were more active (p < 0.01) in cold task compared with baseline task. Blue—purple areas indicate brain regions that were more active (p < 0.01) in baseline task than in cold task. Left anterior insula (arrowhead) and right subcentral gyrus (arrow) are active during cold task; z-axis slice location is 12.

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