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AJR 2001; 177:1437-1445
© American Roentgen Ray Society


Pictorial Essay

Electron Beam CT of the Coronary Arteries

Cross-Sectional Anatomy for Calcium Scoring

Alexander Sevrukov1, Vladimir Jelnin and George T. Kondos

1 All authors: Department of Medicine, Section of Cardiology, University of Illinois at Chicago, 840 S. Wood St. (M/C 787), Chicago, IL 60612.

Received May 4, 2001; accepted after revision July 3, 2001.

 
Address correspondence to G. T. Kondos.


Introduction
Top
Introduction
Methods
Heart Axis
Left Main Coronary Artery
Left Anterior Descending Artery...
Left Circumflex Artery and...
Right Coronary Artery and...
Common Errors and Pitfalls...
References
 
Scanning of the coronary arteries is increasingly used for the detection and quantification of calcium deposits. Accurate evaluation requires a thorough knowledge of coronary artery and venous anatomy (Fig. 1) and an appreciation of the common pitfalls of coronary artery imaging.



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Fig. 1. Coronary arteries and veins in left anterior oblique view. Left coronary system consists of left main coronary artery (LMCA), left circumflex artery (LCx), left anterior descending artery (LAD), diagonal branches (DB), and obtuse marginal branch (OM). Right coronary system consists of right coronary artery (RCA), conus branch (CB), right ventricular branch (RVB), acute marginal branch (AM), posterior descending artery (PDA), and posterior left ventricular branch (PLV). Coronary venous system is composed of coronary sinus (CS), great cardiac vein (GCV), middle cardiac vein (MCV), and small cardiac vein (SCV).

 

The nonopacified coronary arteries can be readily identified on electron beam CT because the lower CT density of periarterial fat produces marked contrast to blood in the coronary vessels, whereas the mural calcium is evident because of its high CT density relative to blood [1,2,3].


Methods
Top
Introduction
Methods
Heart Axis
Left Main Coronary Artery
Left Anterior Descending Artery...
Left Circumflex Artery and...
Right Coronary Artery and...
Common Errors and Pitfalls...
References
 
Electron beam CT scans were obtained with 100-msec scanning time and 3-mm scan width using a C-150 scanner (Imatron, South San Francisco, CA). Images were acquired in a single breath-hold and triggered from an ECG at 60% of the R-R interval using an ECG trigger monitor (Ivy Biomedical, Branford, CT). Electron beam CT image exporting was performed using NetraMD image analysis software (ScImage, Los Altos, CA).


Heart Axis
Top
Introduction
Methods
Heart Axis
Left Main Coronary Artery
Left Anterior Descending Artery...
Left Circumflex Artery and...
Right Coronary Artery and...
Common Errors and Pitfalls...
References
 
Coronary artery imaging is carried out using neutral axis projection. The heart is imaged in oblique planes because the heart axis is not perpendicular to the scanner gantry in this configuration (Fig. 2A).



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Fig. 2A. Position of heart in thoracic cavity and relationship between ostia of left and right coronary arteries in 52-year-old asymptomatic man. Coronal reconstructed electron beam CT image shows relationship of heart and body axes. In neutral axis projection, body axis (A) is perpendicular to scanner gantry (C). However, heart axis (B) in thoracic cavity is oriented obliquely (angled approximately 25° from right to left and approximately 15° from posterior to anterior, relative to body axis). Because heart axis is at angle to body axis, electron beam CT images obtained in this configuration are oblique sections of heart. AAo = ascending aorta, PT = pulmonary trunk, LV = left ventricle, RA = right atrium.

 

The ostia of the left main coronary artery and the right coronary artery are located at nearly the same distance from the aortic valve when measured along the axis of the ascending aorta. However, these vessels typically come into view at different tomographic levels (Fig. 2B).



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Fig. 2B. Position of heart in thoracic cavity and relationship between ostia of left and right coronary arteries in 52-year-old asymptomatic man. Curved multiplanar reformatted electron beam CT image shows distance between left main coronary artery (LMCA) and right coronary artery (RCA), which may span 9-27 mm (3-9 slices). LMCA typically comes into view at more cranial tomographic levels than RCA. AAo = ascending aorta, LV = left ventricle.

 


Left Main Coronary Artery
Top
Introduction
Methods
Heart Axis
Left Main Coronary Artery
Left Anterior Descending Artery...
Left Circumflex Artery and...
Right Coronary Artery and...
Common Errors and Pitfalls...
References
 
The left main coronary artery arises from the left aortic sinus (Fig. 2B) and passes behind the pulmonary trunk. It usually travels horizontally or in a slightly cephalad direction and divides into the left anterior descending and left circumflex arteries (Fig. 3). Occasionally, the left main coronary artery terminates in a trifurcation, giving rise to an intermediate coronary artery that is directed laterally [4] (Fig. 4A,4B).



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Fig. 3. Left main coronary artery bifurcation in 56-year-old asymptomatic woman. Electron beam CT image shows left main coronary artery (LMCA) dividing into left anterior descending artery (LAD) and left circumflex artery (LCx). Point of LMCA division is important anatomic landmark for delimitation of LMCA and LAD. Note close relationship of LCx and great cardiac vein (GCV) in left atrioventricular sulcus. Any hyperattenuating foci arising from GCV can be disregarded because calcium is not deposited in veins. AAo = ascending aorta, PT = pulmonary trunk, LA = left atrium, RSPV = right superior pulmonary vein, LSPV = left superior pulmonary vein, SVC = superior vena cava.

 


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Fig. 4A. Intermediate coronary artery in 55-year-old man with chest pain. Electron beam CT image shows intermediate coronary artery (ramus intermedius, RI) arising between left anterior descending artery (LAD) and left circumflex artery (LCx). Calcium is present at ostia of LCx and RI and in proximal LAD. Calcium deposits detected in RI should be reported as LAD calcium. AAo = ascending aorta, PT = pulmonary trunk, LA = left atrium, LAA = left atrial appendage, RSPV = right superior pulmonary vein, LSPV = left superior pulmonary vein, RAA = right atrial appendage, SVC = superior vena cava.

 


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Fig. 4B. Intermediate coronary artery in 55-year-old man with chest pain. Left anterior oblique caudal view of left coronary arteriogram shows RI arising between LAD and LCx. Arteriogram shows 30% stenosis of proximal LAD (arrowhead). DB = diagonal branch, OM1 = first obtuse marginal branch, OM2 = second obtuse marginal branch.

 


Left Anterior Descending Artery and Its Branches
Top
Introduction
Methods
Heart Axis
Left Main Coronary Artery
Left Anterior Descending Artery...
Left Circumflex Artery and...
Right Coronary Artery and...
Common Errors and Pitfalls...
References
 
The left anterior descending artery passes initially behind the pulmonary trunk and then comes forward between that vessel and the left atrial appendage to reach the anterior interventricular sulcus (Fig. 5). When the coronary arteries are imaged from the base of the heart to the apex, the left anterior descending artery is usually the first coronary artery that comes into view, followed by the left main coronary artery [5].



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Fig. 5. Proximal left anterior descending artery (LAD) in 49-year-old asymptomatic man. Electron beam CT image shows LAD passing between pulmonary trunk and left atrial appendage. Proximal LAD, which travels horizontally, is shown in longitudinal section. Diagonal branch (DB) comes into view at this level. This branch traverses anterolateral aspect of left ventricle. LMCA = left main coronary artery, AAo = ascending aorta, PT = pulmonary trunk, LAA = left atrial appendage, RSPV = right superior pulmonary vein, LSPV = left superior pulmonary vein, RPA = right pulmonary artery, LPA = left pulmonary artery, RAA = right atrial appendage.

 

The left anterior descending artery gives rise to septal and diagonal branches. Diagonal branches are frequently identified on electron beam CT scans (Fig. 5).


Left Circumflex Artery and Its Branches
Top
Introduction
Methods
Heart Axis
Left Main Coronary Artery
Left Anterior Descending Artery...
Left Circumflex Artery and...
Right Coronary Artery and...
Common Errors and Pitfalls...
References
 
Immediately after the left circumflex artery arises from the left main coronary artery division, it angles posteriorly to pass below the left atrial appendage and enters the left atrioventricular sulcus (Fig. 6A,6B). A short segment of the proximal left circumflex artery is typically seen at the level of the left main coronary artery division (Figs. 3 and 4A).



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Fig. 6A. Left circumflex artery (LCx) segments in 56-year-old asymptomatic man. Electron beam CT image shows level of left ventricular outflow tract (LVOT). Mid LCx adjoins great cardiac vein (GCV) medially in left atrioventricular sulcus. Note calcium deposits in LCx and left anterior descending artery (LAD). RVOT = right ventricular outflow tract, RA = right atrium, RCA = right coronary artery, LA = left atrium, RIPV = right inferior pulmonary vein, LIPV = left inferior pulmonary vein, DB = diagonal branch.

 


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Fig. 6B. Left circumflex artery (LCx) segments in 56-year-old asymptomatic man. Electron beam CT image shows level of coronary sinus (CS). Distal LCx courses in left atrioventricular sulcus and reaches nearly as far as crux. On diaphragmatic surface of heart, diameter of LCx becomes progressively smaller, whereas diameter of great cardiac vein gradually enlarges until it ultimately joins CS. Note small calcium deposit in RCA. RA = right atrium, LV = left ventricle, RV = right ventricle.

 

The left circumflex artery generally gives rise to three obtuse marginal branches, of which the second is generally the largest [4]. This branch is frequently identified on electron beam CT scans (Fig. 7A,7B).



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Fig. 7A. Left circumflex artery (LCx) branches in 50-year-old man with chest pain. Electron beam CT image shows LCx and two obtuse marginal branches (OM 1 and OM 2) traversing posterolateral aspect of left ventricle. LAD = left anterior descending artery, RCA = right coronary artery, GCV = great cardiac vein, RA = right atrium, LA = left atrium, LIPV = left inferior pulmonary vein, RVOT = right ventricular outflow tract, LVOT = left ventricular outflow tract.

 


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Fig. 7B. Left circumflex artery (LCx) branches in 50-year-old man with chest pain. Anteroposterior left coronary arteriogram shows obtuse marginal branch (OM) of LCx. Arteriogram shows 20% stenosis of proximal LAD (arrowhead). LMCA = left main coronary artery, SB = septal branch, DB1 = first diagonal branch, DB2 = second diagonal branch, DB3 = third diagonal branch.

 


Right Coronary Artery and Its Branches
Top
Introduction
Methods
Heart Axis
Left Main Coronary Artery
Left Anterior Descending Artery...
Left Circumflex Artery and...
Right Coronary Artery and...
Common Errors and Pitfalls...
References
 
The right coronary artery arises from the right aortic sinus (Fig. 2A,2B). It passes first between the right ventricular outflow tract and the right atrial appendage and then runs in the right atrioventricular sulcus (Fig. 8A,8B,8C,8D). The initial 15- to 25-mm portion of the right coronary artery follows the horizontal course. Hence, it is usually seen in longitudinal section (Fig. 8B). The subsequent segments of the proximal and mid right coronary arteries are cut in cross section during their course in the right atrioventricular sulcus (Fig. 8C).



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Fig. 8A. Right coronary artery (RCA) segments in 56-year-old woman with chest pain. Left anterior oblique caudal view of right coronary arteriogram shows 40% stenosis of proximal RCA (arrowhead). Note large conus branch (CB), right ventricular branch (RVB), posterior descending artery (PDA), and posterior left ventricular branch (PLV). 1, 2, and 3 indicate levels of imaging.

 


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Fig. 8B. Right coronary artery (RCA) segments in 56-year-old woman with chest pain. At level 1, electron beam CT image shows proximal RCA following horizontal course, which permits visualization of relatively long segment of this vessel in longitudinal section. LAD = left anterior descending artery, RVOT = right ventricular outflow tract, RA = right atrium, LA = left atrium, AAo = ascending aorta, LCx = left circumflex artery.

 


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Fig. 8C. Right coronary artery (RCA) segments in 56-year-old woman with chest pain. At level 2, electron beam CT image shows mid RCA following right atrioventricular sulcus. This mid segment of artery is shown in cross section. RA = right atrium, LA = left atrium, RV = right ventricle, LV = left ventricle, LAD = left anterior descending artery, LCx = left circumflex artery, RVB = right ventricular branch.

 


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Fig. 8D. Right coronary artery (RCA) segments in 56-year-old woman with chest pain. At level 3, electron beam CT image shows distal RCA following right atrioventricular sulcus toward crux. This distal segment of artery is shown in longitudinal section. RV = right ventricle, LV = left ventricle, IVC = inferior vena cava.

 

The distal right coronary artery begins just beyond the acute marginal branch and passes horizontally along the diaphragmatic surface of the heart, where it can be seen in longitudinal section (Fig. 8D).

The right coronary artery branches, frequently identified on electron beam CT scans, are the conus branch (Figs. 8A and 9A), the right ventricular branches (Fig. 8C), the acute marginal branch (Fig. 9B), and the posterior descending artery (Fig. 10A), which arises from a dominant right coronary artery in 85% of individuals [6]. Adjoining the middle cardiac vein, the posterior descending artery runs anteriorly in the posterior interventricular sulcus. The quantification of posterior descending artery calcium is hindered in many individuals by excessive image noise levels, which may be created by the liver entering the field of view at this level [7] (Fig. 10A).



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Fig. 9A. Proximal branches of right coronary artery (RCA) in 52-year-old man with chest pain. Electron beam CT image shows conus branch (CB) of RCA. This branch passes anteriorly and upward over pulmonary trunk and right ventricular outflow tract (RVOT). Note calcium in CB. RAA = right atrial appendage, LAA = left atrial appendage, RPA = right pulmonary artery, LPA = left pulmonary artery, LSPV = left superior pulmonary vein, AAo = ascending aorta, SVC = superior vena cava.

 


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Fig. 9B. Proximal branches of right coronary artery (RCA) in 52-year-old man with chest pain. Electron beam CT image shows acute marginal branch (AM) of RCA. This branch follows acute margin of heart. RA = right atrium, LV = left ventricle, RV = right ventricle, IVC = inferior vena cava, MCV = middle cardiac vein.

 


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Fig. 10A. Distal branches of right coronary artery in 65-year-old man with chest pain. RV = right ventricle, LV = left ventricle, IVC = inferior vena cava, L = liver. Electron beam CT image shows posterior descending artery (PDA), which travels anteriorly in posterior interventricular sulcus, adjoined by middle cardiac vein (MCV). Calcium deposits are present in proximal PDA and posterior left ventricular (PLV) branch.

 

After giving rise to the posterior descending artery, a dominant right coronary artery continues beyond the crux (a point on the diaphragmatic surface of the heart where the left atrioventricular, right atrioventricular, and posterior interventricular sulci come together) in the left atrioventricular sulcus where it terminates, giving rise to the posterior left ventricular branch (Figs. 10A and 10B). Calcium deposits in this branch may be misinterpreted as distal left circumflex artery calcium.



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Fig. 10B. Distal branches of right coronary artery in 65-year-old man with chest pain. RV = right ventricle, LV = left ventricle, IVC = inferior vena cava, L = liver. Electron beam CT image shows PLV branch of right coronary artery. This branch runs in left atrioventricular sulcus. Calcium deposits are present in proximal PDA and PLV branch. MCV = middle cardiac vein.

 


Common Errors and Pitfalls in Coronary Artery Calcium Detection
Top
Introduction
Methods
Heart Axis
Left Main Coronary Artery
Left Anterior Descending Artery...
Left Circumflex Artery and...
Right Coronary Artery and...
Common Errors and Pitfalls...
References
 
The misinterpretation of mitral annular and aortic root calcification may result in a spuriously elevated coronary artery calcium score (Figs. 11 and 12). Left circumflex artery calcium can be distinguished from mitral annular calcification by the presence of a layer of periarterial fat. In contrast, mitral annular calcification is intimately related to the myocardium, has irregular borders, and usually shows an extensive amount of calcium.



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Fig. 11. Mitral annular calcification (MAC) in 68-year-old asymptomatic man. Electron beam CT image at level of aortic valve (AoV) shows calcification at left atrioventricular junction consistent with calcified mitral valve annulus. Note calcified aortic valve leaflets. RA = right atrium, LA = left atrium, RV = right ventricle, LV = left ventricle.

 


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Fig. 12. Aortic root calcification in 69-year-old asymptomatic man is shown on electron beam CT image. Aortic root calcium may extend into ostia of left main and right coronary arteries (arrowheads). Inclusion of aortic root calcium in total coronary artery calcium score will result in falsely high value. AAo = ascending aorta, PT = pulmonary trunk, LA = left atrium, RAA = right atrial appendage, LAA = left atrial appendage, RSPV = right superior pulmonary vein, LSPV = left superior pulmonary vein, SVC = superior vena cava.

 

Intracoronary stents introduced during the percutaneous transluminal coronary angioplasty are frequently indistinguishable from coronary artery calcium deposits on electron beam CT scans, necessitating a thorough patient history to identify any prior cardiovascular interventional procedures (Fig. 13A,13B,13C). A similar error may result from implanted metal clips used during coronary artery bypass surgery (Fig. 14A,14B).



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Fig. 13A. Intracoronary stents in 60-year-old man with history of percutaneous transluminal coronary angioplasty. Intracoronary stents manifest as hyperattenuating objects confined to vessel wall and characterized by well-defined contour and circular appearance in cross section. Electron beam CT image shows two intracoronary stents: one in main trunk of left anterior descending artery (LAD) and one in diagonal branch (DB) of LAD. AAo = ascending aorta, PT = pulmonary trunk, RAA = right atrial appendage, LA = left atrium.

 


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Fig. 13B. Intracoronary stents in 60-year-old man with history of percutaneous transluminal coronary angioplasty. Intracoronary stents manifest as hyperattenuating objects confined to vessel wall and characterized by well-defined contour and circular appearance in cross section. Electron beam CT image shows intracoronary stent in proximal right coronary artery (RCA) and calcium deposit in mid LAD. LA = left atrium, RAA = right atrial appendage, RVOT = right ventricular outflow tract, LVOT = left ventricular outflow tract, LCx = left circumflex artery.

 


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Fig. 13C. Intracoronary stents in 60-year-old man with history of percutaneous transluminal coronary angioplasty. Intracoronary stents manifest as hyperattenuating objects confined to vessel wall and characterized by well-defined contour and circular appearance in cross section. Electron beam CT image shows intracoronary stent producing characteristic circular appearance in cross section of mid RCA. RA = right atrium, LA = left atrium, RV = right ventricle, LV = left ventricle, LAD = left anterior descending artery, OM = obtuse marginal branch, GCV = great cardiac vein.

 


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Fig. 14A. Implanted metal clips in 55-year-old man with history of coronary artery bypass surgery. Electron beam CT image shows surgical clips (arrows) on right aspect of ascending aorta (AAo) and in area of left anterior descending artery. Note streak artifacts originating from metal clips. PT = pulmonary trunk, RPA = right pulmonary artery, LAA = left atrial appendage, LSPV = left superior pulmonary vein, SVC = superior vena cava.

 


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Fig. 14B. Implanted metal clips in 55-year-old man with history of coronary artery bypass surgery. Electron beam CT image shows surgical clips (curved arrow) in area of distal right coronary artery. Note streak artifacts originating from metal clips. Calcium is present in distal right coronary artery and posterior descending artery (PDA). IVC = inferior vena cava, RA = right atrium, RV = right ventricle, MCV = middle cardiac vein.

 

The assessment of coronary artery calcium distribution may be difficult when calcium in the left main coronary artery extends into the left anterior descending and left circumflex arteries (Fig. 15).



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Fig. 15. Calcium deposition at left main coronary artery bifurcation in 52-year-old man with chest pain. Electron beam CT image shows left main coronary artery (LMCA) calcium extending into both left anterior descending (LAD) and left circumflex (LCx) arteries. Assignment of calcium deposits to appropriate arteries may require manual segmentation. AAo = ascending aorta, PT = pulmonary trunk, LA = left atrium, RSPV = right superior pulmonary vein, SVC = superior vena cava, RAA = right atrial appendage.

 

High velocity of the right coronary artery during the cardiac cycle [8] may result in a blurred image of calcium deposits, which may lead to a falsely elevated right coronary artery calcium score (Figs. 16 and 17).



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Fig. 16. Right coronary artery motion artifact in 56-year-old asymptomatic woman. Electron beam CT image shows calcium (arrow) in proximal right coronary artery. Crescent shape of calcium deposit indicates motion artifact, common finding in proximal and mid portions of right coronary artery. AAo = ascending aorta, RVOT = right ventricular outflow tract, RA = right atrium, LA = left atrium.

 


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Fig. 17. Right coronary artery calcium in 58-year-old man with chest pain. Electron beam CT image shows right coronary artery calcium deposit with well-defined borders (arrow). This normal image of right coronary artery calcium is free of motion artifacts. RVOT = right ventricular outflow tract, LVOT = left ventricular outflow tract, RA = right atrium, LA = left atrium.

 


Acknowledgments
 
We thank David R. Klein and Grace Walczak for their valuable contributions to the preparation of this manuscript.


References
Top
Introduction
Methods
Heart Axis
Left Main Coronary Artery
Left Anterior Descending Artery...
Left Circumflex Artery and...
Right Coronary Artery and...
Common Errors and Pitfalls...
References
 

  1. Stanford W, Thompson BH. Imaging of coronary artery calcification: its importance in assessing atherosclerotic disease. Radiol Clin North Am 1999;37:257 -272[Medline]
  2. Wexler L, Brundage B, Crouse J, et al. Coronary artery calcification: pathophysiology, epidemiology, imaging methods, and clinical implications—a statement for health professionals from the American Heart Association. Circulation 1996;94:1175 -1192[Free Full Text]
  3. Rumberger JA, Brundage BH, Rader DJ, Kondos GT. Electron beam computed tomographic coronary calcium scanning: a review and guidelines for use in asymptomatic persons. Mayo Clin Proc 1999;74:243 -252[Abstract]
  4. Kondos GT, Shanes JG, Brundage BH. Coronary arteriography including quantitative estimation of coronary artery stenosis. In: Parmley WW, Chaterjee K, eds. Cardiology, vol. 1. Physiology, pharmacology, diagnosis. Philadelphia: Lippincott, 1986:1 -30
  5. Rabin DN, Rabin S, Mintzer RA. A pictorial review of coronary artery anatomy on spiral CT. Chest 2000;118:488 -491[Abstract/Free Full Text]
  6. Bittl J, Levin D. Coronary arteriography. In: Braunwald E, ed. Heart disease: a textbook of cardiovascular medicine. Philadelphia: Saunders, 1997:240 -272
  7. McCollough CH, Kaufmann RB, Cameron BM, Katz DJ, Sheedy PF 2nd, Peyser PA. Electron-beam CT: use of calibration phantom to reduce variability in calcium quantitation. Radiology 1995;196:159 -165[Abstract/Free Full Text]
  8. Achenbach S, Ropers D, Holle J, et al. In-plane coronary arterial motion velocity: measurement with electron-beam CT. Radiology 2000;216:457 -463[Abstract/Free Full Text]

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