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Fig. 2. —Morphometric measurement of vessel area was obtained by tracing vessel perimeter, delineated by perimeter of external elastic lamina. A represents adventitial area. Perimeter of lumen was traced to define lumen area (L). Perimeter of internal elastic lamina allows definition of area of internal elastic lamina, total area of neointima (N), and L. Medial area (M) was obtained by difference derived from the following formula; vessel area - area of internal elastic lamina. N was obtained by difference derived from subtracting L from area of internal elastic lamina.

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