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Fig. 5. —51-year-old woman with myelofibrosis. Abdominal discomfort prompted clinic visit during which physical examination revealed large spleen. Coronal T1-weighted MR image shows massively enlarged spleen. Patient's symptoms worsened over time, and splenic biopsy was followed by splenectomy. Pathologic examination revealed diffuse infiltration with immature and mature heme elements, which is compatible with extramedullary hemopoiesis.





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